脑源性神经营养因子的分布和TrkB亚型在日益增长的马鹿鹿茸的组织：（Distribution of BDNF and TrkB isoforms in growing antler tissues of red deer）.pdfVIP

Annals of Anatomy 213 (2017) 33–46 Contents lists available at ScienceDirect Annals of Anatomy j o u r n a l h o m e p a g e: w w w. elsev /locate/aanat RESEARCH ARTICLE Distribution of BDNF and TrkB isoforms in growing antler tissues of red deer M. Colitti ∗ Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, via delle Scienze, 206, 33100 Udine, Italy a r t i c l e i n f o a b s t r a c t Article history: Antlers are the cranial appendages of deer that regenerate each year. This renewal provides a model to Received 24 February 2017 explore molecules involved in mammalian organ regeneration. Received in revised form 16 May 2017 The cellular distributions of the brain-derived neurotrophic factor (BDNF) and the isoforms of its Accepted 16 May 2017 cognate receptor Trk tyrosine kinase receptor (TrkB) were localized by immunohistochemistry in sec- tions of growing red deer antler. BDNF and TrkB full length were widely expressed in the integument, Keywords: perichondrium, periosteum and bone. The truncated isoform receptor was particularly evidenced in Antler integument and vascular inner dermis, but very light reaction was observed in cartilage and bone, both BDNF at the site of endochondral and intramembranous ossification. These observations were al