子宫内膜异位（Endometriosis）赵爱民ppt课件.ppt

It is important to individualize the choice of therapy. Therapy must be tailored to the degree of symptomatology the patient’s age her desire to maintain fertility Prognosis： With proper treatment，the prognosis is good for relief of pain and enhancement of fertility in mild to moderate endometriosis. In most cases，hormonal therapy is temporarily effective in controlling symptoms and arresting growth but is generally less effective than surgery in increasing fertility. The recurrent rate is very high. * 乙方有义务提供相应的执业资格证、执业印章等配合甲方工程招投标、承担的工程项目报建及建设施工过程中各类手续办理。 * Endometriosis  ＆ Adenomyosis Zhao aimin M.D., Ph.D., Professor Department Of Obstetrics Gynecology Renji Hospital Affiliated to SJTU School of Medicine Endometriosis Definition: Abnormal growth of endometrial tissue outside the uterine cavity. Incidence and Prevalence: Increase significantly Range from 1～ 50% General population:1～ 2% Infertile women:30～ 50% Occurs primarily in women in 25～ 45s Pathogenesis: Implantation Theory Retrograde Menustration Theory Sampson，1921 Lymphatic and Vascular Dissemination Theory Javert，1952 Coelomic Theory Meyer Genetic Theory Immune System Dysfunction（immunologic theory） Genetic factors： Familial clustering of endometriosis is a common clinical observation. In families with endometriosis，the disease is often confined to the maternal line，and is 7 times more common in first-degree relatives than in the general population. In future studies，evaluation of DNA polymorphism may identify specific genes involved in the development of endometriosis. Immunologic Theory： Lose control of immunologic balance Both cellular immunity and humoral immunity change. Macrophage↑ release IL–1、IL–6、TNF、EGF、FGF et