尿液邻苯二甲酸酯类ppt课件.ppt

Associations between phthalates?exposure and health outcomes of newborns,?pregnant women and precocious puberty girls in Taiwan;What’s Phthalates (PAEs)?;Physico-chemical properties of Phthalates;Applications of phthalates;Application of phthalates;Metabolic pathway of DEHP;Objectives;Objectives;To follow-up our previously established participants in order to determine the correlation between phthalate exposure and thyroid hormones in pregnant women and newborns. ;; Newborns’ health Anogenital distance Gestational age Urine sample Phthalate monoesters Serum Cord blood TSH,T3, T4, FT4 Phthalate monoesters;Measured Parameters ;Measured Parameters ;Table I-1 Demographic characteristics of study participants (n = 76).;;Hormones a;;Figure I-1. Correlation between (A) free thyroxine (FT4), (B) thyroxine (T4) and log MBP (ppb) and MBP-c level in pregnant women at the 2nd trimester. ;Table I-5. Multivariate linear regression between serum FT4 and T4 levels, and their corresponding urinary phthalate monoesters (FT4: R-square= 0.240; T4: R-square= 0.187)a. ;Table II-1 Physical examination of male and female newborns (n = 65).;Table II-2 Concentrations of five phthalate monoesters in amniotic fluid from female and male infants (ng/mL, n=64)1.;Figure II-1 Distribution plot of MBP levels in maternal urine and amniotic fluid (n=59). All the data were log-transformed.;Table II-3 Distribution of health status in females categorized by median levels of phthalate monoester in amniotic fluid (-AF) (n = 31).;Table II-4. Distribution of health status in boys category by median levels of phthalate monoester in amniotic fluid. (n = 33).;;Figure II-2 (A) Linear regressions between MBP in amniotic fluid and AGI-W in females at birth (n=29, R2=0.14, p=0.043); (B) Linear regressions between MBP in amniotic fluid and AGI-L in females at birth (n=29, R2=0.16, p=0.032).;Figure III-3 Multiple regression of AGI, MBP in amniotic fluid and gestational age adjustment of gestational age and other ph