我国老年人钙化性瓣膜病的研究现状和展望王士雯ppt课件.ppt

Clinical and Basic Research on Redegenerative Valvular Heart Disease and Vascular Calcification;Background;Background;Study Contents;Follow-up Research on Clinical Epidemiology of RVHD;Large scale epidemiologic analysis on RVHD and vascular calcification in the elderly;Mobility of RVHD and Relative Risk Factor;CAS：颈动脉粥样硬化； SDVHD：退行性心脏瓣膜病；IMT：颈动脉内膜－中膜厚度;Alkaline phosphatase might be an initiator of vascular calcification. High homocystine level contributes to Ectopic calcipication MMP-3 protein level was upregulated in aortic calcification,which might accelerate calcification by certain pathway. Many factors are involved in the aortic calcification, including SMC, TGF-β、and IGF-1 et al. Human KARP-1 –binding protein and KIAA0470 protein might play roles in aortic calcification. ;clinical pathology of RVHD;Research of Potential prevention and treatment of Statin on RVHD as well as Valvular Calcification;Effect of Provastatin on Valvular Calcification and Possible Mechanism;50μm ×50μm;Clinical Research of Statin in Early Prevention and HF mortality;Typical case 1：;Typical case 2：;Innovations ;Application and social effect; Future steps ;谢谢！