Cancer_Stem_Cells癌症干细胞.pdf

Cancer Stem Cells Isolate, Verify, and Investigate ISOLATE VERIFY INVESTIGATE The CSC Hypothesis Like all stem cells, oncogenically transformed cancer stem cells Unlike the differentiated cancer cells in a tumor, xeno- (CSCs) are defined by their ability for self-renewal and multi potency. transplantation of human CSCs gives rise to new tumors in The CSC hypothesis states that, although CSCs represent a rare immunodeficient animal models. Although inconsistencies in population of cells within a tumor, their high tumorigenic capacity these studies have questioned the validity of the CSC hypothesis, drives tumorigenesis. Due to their intrinsic stem cell-like properties, it is likely that variable findings result from differences in assay CSC proliferation generates more CSCs and all the differentiated sensitivity and quantification methodology. An overriding exper- cell types that compose the bulk of the tumor. imental limitation for CSC researchers is the ability to isolate CSCs and verify CSC marker expression. To address this need, Differentiated cancer cells have been shown to proliferate at a we present our product offering for the isolation, verification, faster rate than CSCs but have little tumor-initiating potential. Because CSCs exhibit increased resistance to toxic and chemical and investigation of CSCs. insults, this specific subpopulation of cells is believed to underlie resistance to chemotherapy and disease relapse. In fact, the CSC model suggests that all CSCs must be eradicated to eliminate a learn more | RnDS/CSCProducts tumor and prevent its recurrence. Malignancy-sp