全真一气汤治疗慢性心力衰竭临床效果及对血清体液因子影响.docVIP

全真一气汤治疗慢性心力衰竭临床效果及对血清体液因子影响 　　[摘要]目的 探?全真一气汤治疗慢性心力衰竭（CHF）的临床效果及对血清体液因子的影响。方法 选取我院2014年12月～2016年12月收治的126例CHF患者作为研究对象，按随机数字表法分为常规西药组（对照组）和中西医结合组（观察组），每组63例。对照组给予口服呋塞米、螺内酯、贝那普利及比索洛尔等常规西药治疗，观察组在此基础上加服全真一气汤，两组疗程均为4周。两组治疗前及治疗后8周均行彩色多普勒超声心动图，检测左室射血分数（LVEF）、左室收缩末期容积（LVESV）、左室收缩末期内径（LVESD）、左室舒张末期内径（LVEDD）、左室舒张末期容积（LVEDV）和心排出量（SV），同时检测血清N-末端B型利钠肽前体（N-proBNP）、超敏C反应蛋白（hs-CRP）及肿瘤坏死因子-α（TNF-α）以及血尿常规、血清电解质、肝肾功能等。比较两组的临床疗效、中医症候疗效、心功能指标及不良反应情况。结果 观察组的临床总有效率为95.2%，显著高于对照组的71.4%（P0.05）。观察组的中医症候总有效率为96.8%，显著高于对照组的74.6%（P0.05）。治疗后8周，两组的LVEF、LVEDV、LVESD、LVESV、SV、N-proBNP、hs-CRP和TNF-α水平较治疗前均有改善（P0.05），且观察组明显优于对照组（P0.05）。两组均未见明显不良反应。结论 全真一气汤治疗CHF安全有效，可以改善心功能指标和血清体液因子水平，且无明显不良反应。 　　[关键词]全真一气汤；心力衰竭；超声心动图；体液因子 　　[中图分类号] R541.6 [文献标识码] A [文章编号] 1674-4721（2018）3（a）-0004-04 　　Clinical effect of Quanzhenyiqi Decoction in treating chronic heart failure and influence on serum humoral factors 　　WANG Xian1 LI Hong-wei1 SHI Zhen-dong2 CAO Lei1 　　1.Department of Traditional Chinese Medicine and Western Medicine，Tiefa Coal Industry Group General Hospital Affiliated to Shenyang Medical College，Liaoning Province，Tieling 112700，China；2.VIP Ward，Tiefa Coal Industry Group General Hospital Affiliated to Shenyang Medical College，Liaoning Province，Tieling 112700，China 　　[Abstract]Objective To expore the clinical effect of Quanzhenyiqi Decoction in the treatment of chronic heart failure （CHF） and influence on serum humoral factors.Methods 126 cases of CHF patients treated in our hospital from December 2014 to December 2016 were selected as the research subjects.According to the random number table method，all patients were divided into the conventional western medicine group （the control group） and the combination of traditional Chinese and western medicine group （the observation group），with 63 cases in each group.The control group was treated with conventional western medicine.The observation group was treated with conventional western medicine and Quanzhenyiqi Decoction.Two groups were both treated for