Ti-O膜表面固定不同手性酒石酸和其血液相容性评价.pdf

Material Sciences 材料科学, 2017, 7(3), 345-352 Published Online May 2017 in Hans. /journal/ms /10.12677/ms.2017.73047 Immobilization of Different Chiral Tartaric Acid on Ti-O Surface and Blood Compatibility Evaluation Honghong Han, Yonghong Fan, Ke Wang, Xiaxin Pan, Yajun Weng* Key Laboratory of Advanced Technologies of Materials, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu Sichuan th th th Received: May 6 , 2017; accepted: May 24 , 2017; published: May 27 , 2017 Abstract Chirality is one of the basic characteristics of life system, which has a high degree of chiral selec- tivity, surface chirality may significantly affect the biological function of biomaterials. In this pa- per, different chiral tartaric acid molecules were immobilized on the surface of Ti-O films. XPS test results showed the peak of nitrogen appeared on the samples which had deposited dopamine, the ratio of nitrogen to carbon was increased when hexamethylendiamine was introduced. When chiral tartaric acid was grafted, the ratio of oxygen to carbon was increased. XPS results showed that all surfaces had been successfully prepared. The water contact angle test results showed that no difference was present on the L-surface and D-surface, indicating that surface chirality had lit- tle effect on surface hydrophobicity. The effects of chirality on the blood compatibility of materials were evaluated by fibrinogen denaturation test and platelet adhesion and activation assay in vitro. Compared with L-tartaric acid surface, D-tartaric acid surface showed a lower degree of denatura- tion of fibrinogen, less platelet adhesion and a lower degree of platelet activation. These results indicate that chirality