泰州市人民医院2016年血培养阳性病原菌地分布及耐药性分析.docVIP

泰州市人民医院2016年血培养阳性病原菌的分布及耐药性分析 【摘 要】目的：了解泰州市人民医院2016年血培养病原菌的分布和耐药情况。方法：采用BACTEC ALERT 3D 全自动血培养仪；VITEK 2 Compact全自动鉴定系统，链球菌药敏为纸片扩散法（K-B法），真菌药敏采用DL-96 FUNGUS；WHONET5.6软件进行统计分析。结果：2016年全年血培养共检出病原菌380 株，排列前五位的菌种依次为大肠埃希菌（24.2%）、表皮葡萄球菌（14.7%）、人葡萄球菌（12.1%）、肺炎克雷伯菌（8.7%）、金黄色葡萄球菌（7.9%）。血培养病原菌主要分布于：新生儿ICU(NICU)、感染科、ICU、消化科。大肠埃希菌和肺炎克雷伯菌超广谱β-内酰胺酶（extended spectrumβ lactamases，ESBLs） 检出率分别为53.3%、33.3%。耐甲氧西林金黄色葡萄球菌（methicillin re-sistant Staphylococcus aureus，MRSA）检出率为44.4%，葡萄球菌未发现对利奈唑胺、万古霉素、奎奴普丁/达福普汀、替加环素耐药的菌株。结论：血培养病原菌在不同科室的分布和耐药性不同。 [关键词] 血培养；病原菌分布；耐药率 [中图分类号] R446.5 [文献标志码] A  Analysis of distribution and resistance of pathogens isolated from blood culture Xu Juan1, Lu Tao-hong1, Zhang qing-fang1,*, Zhou cheng-lin1,* (1 Department of Laboratory Medicine, Jiangsu Taizhou People’s Hospital，Taizhou 225300,China) [Abstract] Objective：To investigate the distribution and resistance of pathogens isolated from blood culture of patients in the Jiangsu Taizhou People’s Hospital in 2016. Methods: All blood samples were cultured by BACTEC ALERT 3D. Automatic detection machine of VITEK-2 Compact was used for identification of bacteria and fungus, as well as the susceptibility of nonfastidious bacteria. Susceptibility of streptococcus was tested by K-B method while susceptibility of fungus was tested by DL-96 FUNGUS. Whonet 5.6 software was used for statistical analysis. Results: The total of pathogen strains isolated from blood culture in 2016 was 380. The top 5 bacteria were Escherichia coli (24.2%), Staphylococcus epidermidis (14.7%), Staphylococcus homin (12.1%), Klebsiella pneumonia (8.7%), Streptococcus (7.9%). The pathogens of blood culture were mainly isolated from the department of neborn-intensive care unit, infection, intensive care unit, Gastroenterology dept. The resistance rates of Escherichia coli and Klebsiella pneumonia to extended spectrumβ lactamases (ESBLs) were 53.3%, 33.3%. Staphylococcus aureus had a 44.4% resistance rate to methicillin, while all of the three a