无关供者与同胞相合供者异基因造血干细胞移植对急性淋巴细胞.PDF

102 ● ● 《中国医学前沿杂志（电子版）》2018 年第10 卷第2 期  论著  DOI ：10.12037/YXQY.2018.02-23 无关供者与同胞相合供者异基因造血干细胞移植 对急性淋巴细胞白血病患儿疗效比较 井远方，唐湘凤 （中国人民解放军海军总医院　儿科，北京　100048） 【摘要】目的 对比分析无关供者（unrelated donor ，URD ）与同胞相合供者（type matching sibling donor ，MSD ）异基因造 血干细胞移植（allpgeneic hematopoietic stem cell transplantation ，allo-HSCT ）对急性淋巴细胞白血病（acute lymphoblastic leukemia ，ALL ）患儿的临床疗效。方法 选择2008 年3 月至2015 年3 月于本院行allo-HSCT 治疗的ALL 患儿58 例为研 究对象，根据供者来源将入选患儿分为URD 组（24 例）和MSD 组（34 例），比较两组患儿移植后造血重建情况、并发症 发生率及随访生存情况。结果 两组患儿造血重建率、血小板重建时间、中性粒细胞重建时间、移植后相关并发症[ 急性移 植物抗宿主病、慢性移植物抗宿主病、肺部感染、巨细胞病毒感染、出血性膀胱炎、EB 病毒感染] 发生率、总生存率及无 P 病生存率比较均无显著差异（ ＞0.05 ）。结论 URD allo-HSCT 治疗儿童ALL 的疗效与MSD allo-HSCT 相当，可将其作 为无同胞人类白细胞抗原匹配ALL 患儿的治疗选择。 【关键词】无关供者；同胞相合供者；异基因造血干细胞移植；急性淋巴细胞白血病；儿童 Comparison of the effects of unrelated donor and type matching sibling donor allogeneic hematopoietic stem cell transpl anta- tion for children with acute lymphoblastic leukemia JING Yuan-fang, TANG Xiang-feng (Department of Paediatrics, Navy General Hospital, Beijing 100048, China) Corresponding author: TANG Xiang-feng, E-mail: 163.com Abstract Objective 【 】 　To analyze the clinical efficacy of unrelated donor (URD) and type matching sibling donor (MSD) allogeneic hematopoietic stem cell transplantation (allo-HSCT) for children with acute lymphoblastic leukemia (ALL). Method　 From March 2008 to March 2015, 58 cases of children with ALL treated by allo-HSCT in our hospital were selected as the research objects, according to the donors, they were divided into URD group (24 cases) and MSD group (34 cases). The hematopoietic reconst- itution, incidence of complications and follow-up survival were compared between the two groups after transplantation. Result　 There were no significant differences in the hematopoietic reconstitution rate, platelet reconstruction time, neutrophil reconstruction time, graft versus