婴幼儿腹泻致急性肾损伤临床研究.docVIP

婴幼儿腹泻致急性肾损伤临床研究 　　[摘要]目的 探讨婴幼儿腹泻致急性肾损伤的治疗方法，使对婴儿的身体损伤降到最低。方法 将2014年12月～2015年12月我院确诊的136例腹泻致急性肾损伤的婴儿按照治疗方法的不同，分为A组54例和B组82例，对A组婴儿予补液、纠酸治疗，B组婴儿予扩容、纠酸、酚妥拉明和多巴胺，呋塞米利尿治疗，比较两组的尿量、尿素氮（BUN），肌酐（Cr）、尿酸水平。结果 两组治疗后尿量增加，BUN和Cr均明显好转，但B组治疗后的BUN和Cr、尿酸降低更明显，差异有统计学意义（P0.05）。结论 采用扩容、纠酸、酚妥拉明和多巴胺扩张肾脏小动脉，呋塞米利尿，吸氧，纠正水电解质紊乱等综合治疗婴幼儿腹泻致急性肾损伤，有很好的可操作性和良好的效果。 　　[关键词]婴幼儿；腹泻；急性肾损伤 　　[中图分类号] R723.11 [文献标识码] A [文章编号] 1674-4721（2016）11（a）-0086-03 　　[Abstract]Objective To explore treatment methods of acute kidney injury caused by diarrhea in infants，to minimize the damage to the infant′s body.Methods From December 2014 to December 2015，136 cases diagnosed as acute kidney injury caused by diarrhea in infants in our hospital were divided into group A of 54 cases and group B of 82 cases according to different treatment methods，infants in group A were given rehydration，correcting acid treatment，infants in group B were given expansion，correcting acidosis，Phentolamine and Dopamine and Furosemide diuresis，urine volume，blood urea nitrogen （BUN），creatinine （Cr），uric acid level were compared in two groups.Results The urine volume of two groups increased，Cr and BUN of two groups were significantly improved after treatment，but BUN and Cr，uric acid in group B after treatment decreased more significantly than that in group A，and the difference was statistically significant （P0.05）.Conclusion Expansion，correction of acidosis，Phentolamine and Dopamine dilating renal artery，Furosemide diuresis，oxygen inhalation，correct water and electrolyte disorders and other comprehensive treatment for acute kidney injury caused by diarrhea in infants，which have good operability and good effect. 　　[Key words]Infants；Diarrhea；Acute kidney injury 　　?胗锥?腹泻是一组多病因、多因素引起的以大便次数增多和大便性状改变为特点的消化道综合征，是我国婴幼儿最常见的疾病之一，其中6个月～2岁婴幼儿发病率较高[1-2]。同时此病也是造成小儿营养不良，生长发育障碍的主要原因之一[3]。随着近年来该病的发病率逐渐增高，已经引起了社会各界的广泛关注，为了婴儿患者的生命健康，本研究主要探讨治疗婴幼儿腹泻致急性肾损伤的方法，避免肾衰竭，减少患儿后遗症及家庭经济负担，现报道如下。 　　1资料与方法 　　1.1一般资料 　　选取2014年12月～2015年12月我院确诊的136例腹泻导致急性肾损伤的婴儿患者，按照治疗方法的