子宫内膜非典型增生患者米非司酮与甲基睾丸素治疗前后疗效对比分析.docVIP

子宫内膜非典型增生患者米非司酮与甲基睾丸素治疗前后疗效对比分析 　　【摘要】 目的：对米非司酮与甲基睾丸素治疗子宫内膜非典型增生患者的临床疗效进行对比分析并探讨。方法：选择本医院自2010年8月-2013年2月接诊的经确诊的患者80例，对根据组织学病变程度划分的三种级别的AEH患者进行MP和MT的治疗。对其进行组织病理检查子宫内膜的变化，评估子宫大小及子宫内膜厚度变化情况，并通过患者症状变化来进行综合疗效评价。结果：在记录统计80例患者治疗的疗程中，I级患者所用疗程较短，III级患者的疗程较长，大多数患者需要3～4个疗程；不论是哪种类型的AEH，在使用MP和MT治疗后子宫内膜厚度都较治疗前有明显的减小，且I级的患者变化更为明显。3个级别的AEH患者的临床症状在4个疗程的治疗后，其疗效都有明显的改善。其中有反应的患者占到85%，但是仍有15%的患者对药物治疗无反应甚至发生了癌变。结论：MP和MT能够减小EM的厚度，对不同级别的AEH患者均有良好的治疗疗效，对于轻度和中度的疗效较重度的更为显著，是临床治疗AEH的较佳选择。 　　【关键词】 子宫内膜； 非典型增生； 米非司酮； 甲基睾丸素 　　Explore the Effect of Mifepristone and Methyl Testosterone on Atypical Endometrium Hyperplasia Before and After Treatment/CHEN Chu-zhen， LUO Yun.//Medical Innovation of China，2014，11（31）：114-116 　　【Abstract】 Objective： To observe and explore the effect of mifepristone and methyl testosterone on atypical endometrium hyperplasia before and after treatment. Method： 80 patients with atypical endometrium hyperplasia were diagnosed in the hospital from August 2010 to February 2013 were selected. According to learn the extent of the lesion， patients with AEH were divided in three levels and received MP and MT treatment. Changes in its examination of the endometrium according to histopathological， assess uterine size and endometrial thickness changes， and to carry out a comprehensive evaluation of the efficacy of symptoms in patients with AEH. Result： The regimen of 80 patients in the treatment were recorded， the course of patient-level I was shorter， longer course of treatment in patients with stage III， most patients required three to four courses. Whatever the type of AEH， after treatment of the use of MP and MT endometrial thickness were significantly reduced than before， and the change was more evident in patients with Class I. The three levels of clinical symptoms in patients with AEH after four courses of treatment， its efficacy had improved significantly. Where in the patients had reaction had accounted for 85%， but still 15% of patients unresponsive to medical therapy