C5thecomplementsystem-s-课件.ppt

* * * * * * * * * * * * * Of the three pathways, the alternative and MBL pathways are more Important the first time we are infected by a microorganism, because the antibody required to trigger the classical pathway is not present. pseudopodium * Chapter 3 Regulation of complement system activation Self regulation Fluid-phase regulators Cell-bound control proteins Chapter 4 Biological consequences of complement activation Biologic effects Cell lysis Opsonization调理 and phagocytosis Clearance of immune complex： immune adherent Inflammation炎症 Others：regulation of cells， viral neutralization中和 Cell lysis Form MAC Destroy the target cells Opsonization and phagocytosis Coating of the foreign particles with fragments of complement Prepared for phagocytosis C3b, C4b, iC3b Viral neutralization Coating of the viruses with fragments of complement Block the viruses attaching to susceptible host cell C3b C3b Clearance of immune complex C3b与红细胞表面 CR1结合 运送IC至肝脏、脾脏清除。 Immune adherent： Inflammation C3a, C4a, C5a anaphylatoxin过敏毒素: smooth muscle contraction收缩 capillary毛细管 leakage漏出 Be chemotactic趋化性for neutrophils中性粒细胞 and mononuclear单核细胞 phagocytes 趋化作用 C3a、C5a →促进中性粒细胞趋化 Chemotaxis C5a的生物学作用 1. 激活中性粒细胞 2. 促使中性粒细胞粘附 3. 促进中性粒细胞迁移和趋化作用 4. 激活单核细胞 5. 激活肥大细胞,使之脱颗粒(过敏毒素作用) 血管平滑肌收缩, 血管渗透性增高 Regulation of cells Activate the binded cells Divide the binded cells (二)补体的病理生理学意义 在抗感染防御机制中作为天然免疫和获得性免疫间的桥梁 参与和调节特异性免疫应答 补体系统与凝血、纤溶系统和激肽系统的相互作用 C3b参与捕获、固定Ag C3b参与激活B细胞 第五节 补体与疾病 (一)补体与感染性疾病 抵御致病微生物感染 （正） 病原微生物可借助补体受体入侵细胞 (二)补体与炎症性疾病 (三)补体与异种器官移植 Review questions What are the major biologic effects of complement activation? Compare with the classical, lectin and alternative pathways of complement activation. (you should describe from the following aspects: the activator, participate components, C3 and C5 convertase, and so on. Which components of complement facilitate促进 (a) opsonization? (b) chemotaxis? (c) anaphylax