具有靶向抗癌活性的铂类金属配合物的合成.docx

PAGE 本科学生毕业论文（设计） 题 目 具有靶向抗癌活性的铂类金属配合物的合成 学 院 化学与材料科学学院 专 业 2013级卓越理综 学生姓名 学 号 指导教师 职称 副教授 论文字数 5728 完成日期 2017 年 5 月 11 日 目 录 摘 要 ················································································ 1 关键词 ················································································ 1 Abstract ··············································································· 1 Key Words ············································································· 1 第一章 绪论 1.1 概述··············································································· 2 1.2 本论文的研究内容及选题意义······················································ 3 第二章 实验 2.1 引言··············································································· 5 2.2 实验部分·········································································· 6 2.2.1 试剂与仪器·······································································7 2.2.2 2.2.3 2.2.4 实验现象记录 第三章 结果与讨论 3.1 R2的结果与与讨论··································································· 8 3.2 L2的结果与与讨论··································································· 8 第四章 总结及研究展望 参考文献················································································ 9 致 谢················································································· 11 PAGE PAGE 11 喹啉类锌离子荧光探针的设计与合成 吴玲玲 化学与材料科学学院 摘 要：锌作为人体中的微量元素，在许多生理过程中都起着重要作用，锌离子的紊乱将会引发多种疾病，例如中风、帕金森病、癫痫病等，因此开发有效的锌离子检测方法对于生命科学、医学和环境等领域的相关研究有重大意义,而荧光探针法具有选择性好、灵敏度高及简便快捷等优点。具有生物应用的理想荧光探针应该满足:(1)较好的水溶性；（2）能够定量测定金属离子浓度；（3）较长的激发波长以免造成细胞损害；（4）稳定性高；(5)对金属离子有很高的选择性和灵敏度；（6）易于制备。基于这些要求，本文主要设计、合成了以8-氨基喹啉为荧光团，以cyclen为离子载体的小分子荧光探针，用于检测人体内的微量元素锌。 关键词：锌离子，荧光探针；8-氨基喹啉；Cyclen Design and Synthesis of Quinoline Zn2+ Fluorescence Probe (Wu Lingling，College of Chemistry and Materia