感染性休新生儿的肾上腺皮质功能与多巴胺抵抗分析_王立.pdfVIP

·310 · 　 2010 3 1 35 3 Med J Chin PLA, V l.35, N .3, March 1, 2010　 ·· 感染性休克新生儿的肾上腺皮质功能与多巴胺抵抗分析 王立,李伟,杜立中 [] 　　, (RAI) 。　2005 1 -2009 6 (NICU)50 。28 , 22 。(1μg)(ACTH), 30、60min ,:(NAF)、RAI 。、、(NCIS)。 ,。　50 RAI 19 (38%), NAF 31 (62%)。RAI 1 、、 NAF (P0.05);NCIS, RAI NAF (P0.05)。RAI (68%, 13/19)NAF (10%, 10/31,P0.01)。(n=10)(n=40)(P0.05);30、60min (P0.01)。ACT H 30、60min 70μg/L , 。　ACTH (1μg) RAI (), 70μg/L , 。 　　[]　;;; 　　[]　R726.314　　　　　[]　A 　　　　　[]　0577-7402(2010)03-0310-04 Adrenal cortical function status and catecholamine resistance in newborn with septic shock WANG Li, LI Wei, DU Li-zh ng.Department f Paediatrics, Sec nd Pe plesH spital Affiliated t Hangzh u N rmal University, Hangzh u 310015, China [Abstract] 　Objective　T investigate the functi nal status f adrenal c rtex status in newb rn with septic sh ck, and expl re the diagn stic criteria f relative adrenal insufficiency (RAI)and catech lamine resistance in sh ck.Methods　Fifty newb rns with septic sh ck, 28 males and 22 females, admitted int ne natal intensive care unit (NICU)f Hangzh u Sec nd Pe plesH spital fr m Jan.2005 t Jun.2009, were inv lved in the present study.Serum c rtis l levels f the newb rn patients were measured with radi immun assay at baseline and 30 and 60 minutes after-administrati n f a l w-d se (1μg)f adren c rtic tr phic h rm ne (ACT H).The patients were divided int tw gr ups by maximal c rtis l increment levels:n rmal adrenal functi n (NAF)gr up and RAI gr up.S me clinical fact rs, f r example, the fluid demands n 1st day, sh ck durati n, m rtality, ne natal critical illness sc re (NCIS)and the incidence f catech lamine resistance sh ck, were bserved.Acc rding t pr gn sis these newb rn patients were then divided int tw gr ups: n nsurviv rs and surviv rs.The serum c rtis l levels were c mpared after ACTH test between the tw gr ups.Results　Nineteen RAI and 31 NAF