两种不同麻醉方式应激反应影响.pptVIP

Effect of 2 different anesthesia methods on stress response in neurosurgical patients with hypertension or normalA prospective clinical trial Medicine. 95(35):e4769, August 2016 Ying Chen, MDa, Shan Jiang, MDb, Yong Wu, MDa, Speaker:liujie 2016.10.31 Introduction stress response Neurosurgery trauma, anesthesia, hypoxia, and pain can make the body produce the stress response body produces severe metabolic and homeostasis disorders and immune suppression leading to massive release of hormones and blood sugar into the blood causing serious physiological dysfunction, inflammation, and proliferation（增生） high-sensitivity C-reactive protein (Hs-CRP) （超敏C反应蛋白）concentration increasing dramatically might be a sensitive indicator of inflammation and tissue damage. Introduction hypertension hypertension is a special disease , especially long-term high blood pressure body functions are degraded corresponding pathological changes hypertension patients are more likely to have strong stress response caused by injury of surgery operation compared with non-hypertension patients Introduction anesthesia methods The anesthesia methods may have considerable influence on the surgical stress response and the postoperative immune response Surgery-induced inflammatory response and alteration in cell-mediated immunity seem to be more pronounced after balanced anesthesia by enhancing stress response. The benefit of total intravenous anesthesia might contribute to the prevention of excessive postoperative inflammation. Introduction the relationship between hypertension and anesthesia methods is unclear on the stress response The purpose of this study is to compare the effect of different anesthesia methods on high-sensitivity C-reactive protein (Hs-CRP), blood glucose, and leucocyte levels in neurosurgical patients with hypertension or normal. Materials and methods Subjects Eighty elective neurosurgical patients aged 40 to 65 intracranial aneurysm surgery（脑动脉瘤手术), sellar(蝶鞍