四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响..doc

四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响 】探讨四生汤对甲状腺激素致阴虚证小鼠的治 疗作用及机制。方法：选取健康昆明小鼠60只，随机分成6 组。正常组和阴虚模型组予蒸馏水灌胃，低、中、高剂量四 生汤组为治疗组，生脉饮为阳性对照药物，观察各组小鼠的 一般生活状况并检测其自由活动能力和血清丙二醛的含量。 结果：四生汤能明显改善阴虚模型小鼠的口干、烦躁和体温 升高，提高小鼠的自由活动能力，降低血清丙二醛的含量; 但与生脉饮比较，差异无统计学意义。结论：高、中剂量四 生汤具有良好的养阴清热、生津止渴作用，可提高机体的活 动能力和抗氧化损伤。 关键词】四生汤阴虚身体活动抗氧化剂小鼠 ZhangSF,Chen Z, LiB,ChenHY,LingC Q,WenXY. JChinlnteg rMed/ZhongXiYiJieH eXueBao. XX；6(10)：l 029 1033. RecEivedMarch4, XX； publishe donline0ctoberl5, X X. Freefulltext (PD F) isavailableat. I ndexed/abstractedi nandfulltextlink o utatPubMed. Forwar dlinkingandreferen celinkingviaCrossRef. DOI： /jcimXXlOO 80penAccess Effect sofSishengDecoctio nonspontaneousacti vityandserumconcen trationofmalondial dehydeinmicewithyi ndeficiencysydrome Su fangZHANGl，2，Z heCHENl,BaiLI1，Hon g yunCHENl,Chang quanLINGl,Xin yuWEN 3 DepartmentofTr aditionalChineseMe dicine,ChanghaiHos pital,SecondMilita ryMedicalUniversit y,ShanghaiXX33,Chi na DepartmentofI ntegratedTradition alChineseandWester nMedicine,Pulmonar yHospital, TongjiUn iversity, ShanghaiX X33,China Depart mentofBiochemistry ，ChinesePeoplesLi berationArmyGenera lHospital,BEI jingl 00088,China Object ive：Toassessthethe rapeuticeffectsofS ishengDecoction,acChineseherbalmedicfyindeficiencysynd idhormone,andtomak dyonitsmechanisms. ishengDecoction,ac Chineseherbalmedic fyindeficiencysynd idhormone,andtomak dyonitsmechanisms. Methods：Simultaneo mentwerecarriedout omlydividedintosix ompoundtraditional ine,onamousemodelo romeinducedbythyro ethepreliminarystu usmodelingandtreat .Sixtymicewererand groups：normalgroup ,yindeficiencymode 1group,low ,medium andhigh doseSishe ngDecoctiongroupan dShengmaioralliqui dgroup. Normalgroup andyindeficiencymo delgro叩wereadmini steredwithdoubledi stilledwater. Spont aneousactivityands erumconcentrationo fmalondialdehydein differentgroupswer edetected. Results :Thesymptomsofyind eficiencysyndromes uchasxerostomia,dy sphoriaandfervesce ncewereimprovedint heSishengDecoction groups. Comparedwit htheyindeficie