曲安奈德皮损内注射联合维A酸乳膏外用治疗瘢痕疙瘩的的疗效观察.doc

曲安奈德皮损内注射联合维A酸乳膏外用治疗瘢痕疙瘩的的疗效观察 　　[摘要]目的:了解曲安奈德皮损内注射联合维A酸乳膏外用治疗瘢痕疙瘩的疗效。方法:将55例瘢痕疙瘩患者随机分成治疗组(n=29)和对照组(n=25),治疗组采用曲安奈德皮损内注射,同时联合维A酸乳膏外用;对照组单纯应用曲安奈德皮损内注射。结果:治疗组痊愈率58.62%,总有效率93.11%;对照组痊愈率26.92%,总有效率73.07%。经统计学处理有显著差异。结论:曲安奈德皮损内注射联合维A酸乳膏外用治疗瘢痕疙瘩疗效确切。 　　[关键词]瘢痕疙瘩;曲安奈德;维A酸乳膏 　　[中图分类号]R619+.6 [文献标识码]A [文章编号]1008-6455(2010)02-0-0 　　 　　The curative effect of Triamcinolone acetonide and ratinoic acid to keloid 　　SHAO Yin-hong,REN Hong,KUANG Wei-wei,ZHANG Rui-li 　　(Department of Dermatology,the First Peoples Hospital of Lianyungang, Lianyungang 222002, Jingsu,China) 　　 　　Abstract:ObjectiveTo observe the curative effect of Triamcinolone acetonide combined with ratinoic acid treating keloid. Methods 55 cases of keloid patient were devided into two group randomly, treatment group and control group.The treatment group composed by 29 keloid patients was treated with Triamcinolone acetonide and ratinoic acid;The control group by 25 keloid patients was treated with Triamcinolone acetonide only. Results The curative rate and total efficacy rate of treatment group was 58.62% and 93.11% respectively, while which of control group was 26.92% and 73.07%. The curative rate and total efficacy rate between two groups were significantly different.Conclusion The method of local blockage with Triamcinolone acetonide conbined with ratinoic acid was effective in treating keloid. 　　Key words: keloid; Triamcinolone acetonide; ratinoic acid 　　 　　 瘢痕疙瘩是一个过度增生的致密的纤维组织,通常在皮肤损伤愈合后发生。这种组织增生超出原损伤的范围,不能自发消退,外科切除后易复发[1],治疗上十分棘手,是临床一大难题。2006年9月～2008年9月,我们采用曲安奈德(上海通用药业股份有限公司)皮损内注射后外涂0.1%维A酸乳膏(重庆华邦制药)治疗瘢痕疙瘩患者,并与单纯注射曲安奈德的对照组比较,效果满意,现将结果报道如下。 　　 　　1资料和方法 　　 　　1.1 临床资料:患者55例,随机分为两组:治疗组29例,男16例,女13例,年龄17～53岁,平均36.5岁,病程6个月～12年,平均5.2年;共有瘢痕疙瘩39块,发病部位:前胸部20块,肩背部15块,上臂4块;皮损最大4.5cm×6.5cm×0.8cm,皮损最小0.5cm×1.0cm×0.4cm;对照组26例,男14例,女12例,年龄18～55岁,平均37.1岁,病程8个月～15年,平均5.6年;共有瘢痕疙瘩31块,发病部位:前胸部18块,肩背部11块,上臂2块;皮损最大3.5cm×4.6cm×0.7cm,皮损最小0.6cm×1.2cm×0.5cm。皮损特征:单发或多发的暗红色突起肿块,质地坚硬,边界清楚而不规则,有时呈蟹足状。发病原因:痤疮或马拉色菌毛囊炎等感染引起者45