hsRP与冠心病严重程度及Gensini评分的相关性研究.doc

hs-CRP与冠心病严重程度及Gensini评分的相关性研宄 泰州市第二人民医院心内科 目的：讨论超敏C反应蛋白(hs-CRP)与冠心病及其严重程度间的关系。 方法：选择2012年1月至2013年5月在心内科住院的疑似冠心病患者67例， 其中男性48例，女性19例。所有患者均通过化学发光法测定hs-CRP,所有患者 均行冠状动脉造影，并计算Gensini评分，进一步比较各组间hs-CRP。结果：hs-CRP 在稳定性心绞痛、不稳定性心绞痛、非ST段抬高型心肌梗死及ST段抬高型心肌 梗死患者中的差异有统计学意义(P=0.001)。hs-CRP在冠状动脉无狭窄组、轻度 狭窄组、中度狭窄组及重度狭窄组间的差异有统计学意义(P=0.001),但hs-CRP 与冠状动脉植入支架的个数无关，hs-CRP与Gensini评分相关。结论：hs-CRP与 Gensini评分及冠心病的严重程度相关，是可以预测冠心病的严重程度的辅助指 标。 关键词：hs-CRP, Gensini评分，冠心病 The correlation of between hs-CRP and Gensini score, the severity of coronary heart disease Abstract Objective The aim of the present study was to evaluate the relationship between coronary heart disease and high sensitive C-reactive protein. Method We conducted a study of coronary heart disease from January 2012 to May 2013 in jiangyan peoplersquo;s hospital. Sixty-eight patients (48 male，19 female) were included in our study, we measured circulating level of hs-CRP. And all of the patients were tested through coronary angiography. The severity of coronary atherosclerosis was defined by the Gensini Score System. Results： The serum levels of hs-CRP among stable angina, unstable angina，Non-ST elevated myocardial infarction and ST elevated myocardial infarction were significantly difference (P=0.001)， and also the serum levels of hs-CRP among different severity of coronary heart disease based on Gensini Score System were significantly difference (P=0.001) ? But the serum levels of hs-CRP were not significantly difference among different number coronary stents. Conclusion： The serum levels of hs-CRP can be used as assistant indexes for evaluating degree of Coronary Heart Disease. Key Words： hs-CRP, Gensini score, Coronary Heart Disease -XX- - .1 a 刖g: 冠心病(coronary heart disease, CHD)是世界范围内第五位的致死因素 ［1】。炎症是冠心病发病机理的重要因素之一［2］。超敏C反应蛋白 (hypersensitivity-C-reactive protein, hs-CRP)是一种非特异性炎症标志物，其在 心血管患者中升高［2-5］。CRP是广泛用于冠心病诊断及预后的指标［6］。本文研究 hs-CRP与冠心病的关系。 临床资料： 一般资料 收集2012年1月至2013年5月在姜堰市人民医院心内科住院的67例 冠心病患者。其中男性48例，女性19例，对其进行冠状动脉造影，并对其狭 窄程度进行Gen