《P53基因的研究进展》》-毕业论文.doc

精品 毕业设计（论文） P53基因的研究进展 姓 名 系 别 专 业 化生系 生物技术 导师姓名职称 完 成 时 间 目录 摘要····················································Ⅰ Abstract················································Ⅱ 1 P53基因概述··········································?1 1.1 P53基因的发现······································1 1.2 P53基因的命名·····································?1 1.3 P53基因的研究史·······························?·??2 1.4 研究动态 ········································???3 2 P53基因结构和表达 ·····································4 2.1 基因的结构·······································??4 2.2 基因的表达······································??·5 2.3 基因的失表达····································??·6 3 P53基因的功能·····································???·7 3.1 阻滞细胞周期··································????·7 3.2 促进细胞凋亡··································????·7 3.3 维持基因稳点·································?????·8 3.4 抑制肿瘤血管生成·····························?????·8 3.5 信号通路·······································???·9 4 P53用于治疗方面································???··???10 4.1 基因疗法···········································10 4.2重建P53蛋白活性···································12 4.3 P53治疗效果·······································13 5 P53基因必威体育精装版研究·······································14 参考文献················································18 致谢····················································19 精品 摘要 从1979年发现至今，P53已经历经30多年的岁月，30年说长不长说短不短，人们对p53基因的认识经历了癌蛋白抗原—癌基因—抑癌基因的三重转变，关于p53的文章层出不穷，每当我们觉得离p53的真相接近之时才发现，p53仍是我们最熟悉的陌生人。最近的Nature，PNAS分别发表了p53必威体育精装版研究进展，再度拉近了我们与p53真相间的距离。 关键字：P53基因；肿瘤；基因治疗；重组蛋白  Abstract Found so far in 1979, P53 has been through 30 years of age, 30 years can be a long a short time, peoples understanding of the p53 gene has undergone cancer antigen protein - oncogene - tumor suppressor gene in the triple change, with regard