代谢综合征与甲状腺结节的相关性-内分泌及代谢病学专业论文.docx

PAGE PAGE 10 代谢综合征与甲状腺结节的相关性 中文摘要 目的：分析代谢综合征及其各个组分与甲状腺结节的相关性。探讨影响甲状腺结 节发病率的相关因素。 方法：收集福建省立医院体检中心 2012 年 7 月-2012 年 11 月期间体检的患者的 临床资料，包括病史、身高、体重、生化指标、甲状腺彩超等。符合中华医学会 糖尿病学会关于代谢综合征的诊断标准的 217 例，采用分层整群抽样法选取年 龄、性别与之匹配的非代谢综合征人群 222 例。分析两组间甲状腺结节发病率及 代谢综合征各组分与甲状腺结节的相关性。 结果：代谢综合征组甲状腺结节的患病率为 70.04%，非代谢综合征组甲状腺结 节的患病率为 42.34%，差别有统计学意义（P0.05），对甲状腺结节进行多因 素 logistic 逐步回归分析，结果显示性别、年龄、BMI 及空腹血糖是甲状腺发 生的独立危险因素。（性别：β=0.62，OR=1.86，P0.05; 年龄：β=0.023， OR=1.023，P0.05;BMI：β=1.147，OR=1.158，P0.05; 空腹血糖：β=0.298， OR=1.347，P0.05;）. 结论：代谢综合征患者甲状腺结节的患病率较非代谢综合征者高，BMI 和空腹血 糖可能是甲状腺结节发生的独立危险因素。 关键词：代谢综合征；甲状腺结节；胰岛素抵抗；肥胖 The relationship of metabolic syndrome (Ms) and Ms components with thyroid nodule Abstract Objective: To evaluate The relationship of metabolic syndrome (Ms) and MS components with thyroid nodule，To explore the related factors of affect the incidence of thyroid nodule. Methods：The subjects who received pyhsical checkup at the state hospital of fujian province between July 2012 and novenber 2012 were enrolled in this retrospective study.we collected the imformation include Medical history, height, weight, The biochemical Indicators and thyroid ultrasonography. There were 217 subjects conformed to the Chinese Medical Association of the metabolic syndrome diagnostic criteria. Using stratified cluster sampling method to choose 222 subjects nonmetabolic syndrome matched the age and gender.To analysis of the incidence of thyroid nodule beween the two groups and The relationship of Ms components with thyroid nodule. Results: The prevalence of thyroid nodules in MS was 70.04%, the prevalence of thyroid nodules in non MS was 42.34%, the difference was statistically significant (P 0.05). Multifactor logistic analysis showed that Gender, age, BMI and fasting glucose were independently correlated with the development of thyroid nodule(β vales were 0.62， 0.023，1.147 and 0.298 ，respectively；odds ratios were 1.86，1.023， 1.158 and 1.347，respectively；all P0.05.) Conclusion: The prevalence of the thyro