磁共振弥散加权成像联合血氧水平依赖成像评价IgA肾病病理及其肾功能的分析-内科学(肾脏病学)专业论文.docx

IV IV 摘要 升趋势，提示功能性磁共振对鉴别 IgA 肾病的分级有一定的临床价值。 4、随着 IgA 肾病 GFR 的下降，肾脏皮髓质 ADC 值呈下降趋势，R2*值呈 上升趋势，提示功能性磁共振可用于评价肾脏的滤过功能。 5、随着 IgA 肾病病理 Katafuchi 积分的升高，肾脏皮髓质 ADC 值呈下降趋 势，R2*值呈上升趋势，提示功能性磁共振对于判断 IgA 肾病肾脏病理变化有一 定的意义，可以作为评估肾脏病理损害的一种非侵入性方法。 关键词：IgA 肾病；弥散加权成像；血氧水平依赖成像；肾小球滤过率；病理 Abst Abstract PAGE PAGE VI ABSTRACT Objective: To establish the reference range and evaluation system of the normal renal ADC values and R2* values by completing the diffusion-weighted imaging and the blood oxygenation level-dependent imaging of the healthy volunteers. To investigate the capacity of the diffusion-weighted imaging and the blood oxygenation level-dependent imaging for identifying the grade of IgA nephropathy by comparing the ADC values between the control group and the IgAN group. To investigate the application value of the functional magnetic resonance imaging in evaluating the renal filtration function and the pathological damage of IgA nephropathy by analysing the correlation between the ADC / R2* values and GFR, Katafuchi scores. Methods: Thirty-five patients with IgA nephropathy which were confirmed by renal biopsy were enrolled in this study from January 2014 to December 2014. The patients with nephrarctia, hydronephrosis, nephrolithiasis were eliminated. The glomerular filtration rate were calculated with 99Tcm-DTPA scintigraphy. According to the Lee classification, IgA nephropathy were divided into I-V grade. Using the Katafuchi system to get the scores of the pathological damage of IgA nephropathy. The control group was composed of twenty healthy volunteers matched for sex and age. All of the subjects should stop drug therapy, fast food and water before the examinations, then underwent studies on 3.0T MR scanner with respiratory gating technique and surface phased array coils. The first step were conventional T1WI and T2WI examinations. The second step were DWI with SE-EPI sequence and BOLD with mGRE sequence. Finally, post-processing the datas to obtain the ADC values and R2* va