磁共振弥散加权成像预测食管癌放射敏感性的动物实验研究-肿瘤学专业论文.docx

万方数据 万方数据 目 录 HYPERLINK \l _bookmark0 中文摘要 ·············································································1 HYPERLINK \l _bookmark1 英文摘要 ·············································································3 英文缩写 ·············································································6 HYPERLINK \l _bookmark2 研究论文 磁共振弥散加权成像预测食管癌放射敏感性的动物实验 HYPERLINK \l _bookmark2 研究 HYPERLINK \l _bookmark3 前言 ·············································································7 HYPERLINK \l _bookmark4 材料与方法 ····································································9 HYPERLINK \l _bookmark5 结果 ·············································································13 HYPERLINK \l _bookmark6 附图 ·············································································15 HYPERLINK \l _bookmark7 附表 ·············································································19 HYPERLINK \l _bookmark8 讨论 ·············································································24 HYPERLINK \l _bookmark9 结论 ·············································································28 HYPERLINK \l _bookmark10 参考文献 ·······································································29 HYPERLINK \l _bookmark11 综述 磁共振弥散加权成像在肿瘤学领域应用的研究进展 ··············31 HYPERLINK \l _bookmark12 致谢 ···················································································42 HYPERLINK \l _bookmark13 个人简历 ·············································································43 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 磁共振弥散加权成像预测食管癌放射敏感性 的动物实验研究 摘 要 目的：食管癌是我国常见的消化道恶性肿瘤，放射治疗是食管癌的主 要治疗手段之一，食管癌的放疗疗效很大程度上与其固有的放射敏感性密 切相关，但是在现阶段仍缺乏合理预测食管癌放射敏感性的有效手段。本 研究拟从动物模型层面探讨磁共振弥散加权成像（Diffusion-weighted magnetic resonance imaging, MR-DWI）在预测食管癌放射敏感性的应用价 值，为该种成像技术合理应用于临床提供坚实的基础理论依据。 方法： 1 建立人食管癌 Eca-109 裸鼠移植瘤模型，取建模成功的 24 只荷瘤 裸鼠随机分为实验组（14 只）和对照组（10 只），其中实验组给予单次 剂量 15Gy 的 6MV-X 射线的放射治疗。 2 采用德国西门子 3.0T 核磁共振扫描仪，两组荷瘤裸鼠均在麻醉状 态下于实验组行放射治疗前 1