代谢组学在相关妇科肿瘤中的发展及应用-影像医学与核医学专业论文.docx

重庆医 重庆医科大学硕士研究生学位论文 万方数据 万方数据 英汉缩略语名词对照 英文缩写 NMR 英文全称 Nuclear magnetic resonance 中文全称 核磁共振 MS HR-MAS Mass spectrum High resolution magic angle 质谱 高分辨魔角旋转核磁共振 spinning nuclear magnetic GC-MS resonance Gas chromatography coupled to 气相色谱-质谱 LC-MS mass spectrometry Liquid chromatography - tandem 液相色谱-质谱 ESI mass spectrometry Electrospray ionization 电喷雾离子化 MALDI Matrix-assisted laser 基质辅助激光解吸电离 SELDI-TO desorption/ionization Surface-enhanced laser 蛋白质芯片-飞行时间质谱 F MS desorption/inionation-time of Qq-TOF flight-mass spectra quadrupole –time of flight mass 四级杆-飞行时间-质谱/质谱 MS/MS NIR spectra/ mass spectra Near infrared 近红外光谱 MRS Cho Lip Cr Lac NAA HPLC-MS Magnetic resonance spectroscopy Choline Lipid Creatine Lactate N -acetylaspartate High performance liquid 磁共振波谱 胆碱 脂质 肌酸 乳酸 N-乙酰天门冬氨酸 高效液相色谱质谱 chromatography mass spectrometry 1 PCA Principal component analysis 主成分分析 PLS-DA Partial least squares-discriminant analysis 偏最小二乘法-判别分析 PPV Positive predictive value 阳性预测值 NPV Negative predictive value 阴性预测值 HPV Human papilloma virus 人乳头瘤病毒 CIN Cervical intraepithial neoplasia 宫颈上皮内瘤样变 CSCC Cervical squamous cell carcinoma 宫颈鳞癌 HPLC-DA D-MS-SPE- NMR High performance liquid chromatography-diode-array detector-mass spectrometry-solid phase extraction-nuclear magnetic resonance 高效液相色谱-二极管阵列质谱- 固相萃取-核磁共振 2 代谢组学在相关妇科肿瘤中的发展及应用 摘要 代谢组学作为系统生物组学的一个分支，近年来发展迅速。作为 一门新兴学科，其对探索肿瘤的发生演变具有很大的潜力。本文就目 前代谢组学在妇科肿瘤中的研究进展作一综述，并对代谢组学未来发 展方向进行了展望。 关键词：代谢组学，核磁共振，质谱，核磁共振波谱，妇科肿瘤 3 THE DEVELOPMENT AND APPLICATIONS OF METABONOMICS IN RELATED GYNECOLOGICAL TUMORS ABSTRACT Metabonomics as a branch of system biology has developed rapidly in recent years. As a new scientific discipline, metabonomics has showed big potential in discovery of the formation and development of tumors. The paper reviews the progress about the research of metabonomics in gynecological tumors and its prospects. Key words: metabonomics, nuclear magnetic resonance, mass spectrometry, magnetic resonance spectrum, gynecological tumors 4 代谢组学在相关