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丹皮酚衍生物的合成及其抗肿瘤活性分析-生物医学工程专业论文
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PAGE 6
Schiff base derivatives:
N-[1-(2,4-dihydroxyphenyl)ethylid-ene]benzohydrazide (B1) Bi(2’,4’-dihydroxy-α- methylbenzylidene)-diimine (B2)
Bi(2’,4’-dihydroxy-α-methylbenzyl-idene)-ethylenediimine (B3)
Bi(2’,4’-dihydroxy-α-methylbenzyl-idene)-1,3-trimethylenediimine (B4)
5-methoxy-2-[-1-(propylimino)ethyl]phenol(P1)
Bi(2’-hydroxy-4’-methoxy-α-methyl-benzylidene)-diimine (P2)
Bi(2’-hydroxy-4’-methoxy-α-methyl-benzylidene)-ethylenediimine(P3)
Bi(2’-hydroxy-4’-methoxy-α-methyl-benzylidene)-1,3-trimethylenediim-ine(P4) Metal complexes: CuB1、CuPae、RuP3、RuP4, and CuB1、RuP3、RuP4 three
compounds have not been reported.
3. The anti-tumor activities of eight of the paeonol derivatives were determined by MTT assay. The results showed that paeonol derivatives suppress proliferation of
K562、HL60 cells in a dose-dependent manner. The inhibiting rate of CuB1 on
K562 cells was the highest with IC50 6.94 μg/mL, then IC50 of CuPae, RuP4, RuP3 were 8.58μg/mL ,10.65μg/mL,17.72μg/mL respectively. The inhibiting rate of CuPae on HL60 cells was the highest with IC50 1.96μg/mL, then IC50 of CuB1, RuP4, RuP3 were 2.03μg/mL, 9.31μg/mL, 9.55μg/mL respectively. Which showed CuB1
and CuPae display higher inhibitory activities on proliferation of K562、HL60 cells in
a dose-dependent manner, they could be used as research emphasis to further development of this kind compounds.
Key words: Paeonol derivatives; Schiff base; Synthesis; Anti-tumor activity
缩略词表
表 1 丹皮酚衍生物的缩写表
Tab 1 Abbreviations of paeonol derivatives
缩写代号 中文及英文全称 结构示意图
N’-[1-(2,4-二羟苯基)亚乙基]苯甲 酰肼
B1 N-[1-(2,4-dihydroxyphenyl)ethylid-
ene]benzohydrazide
双(2’.4’-二羟基-α-甲基苄基)-二
HO OH
O
N
NH
亚胺 HO OH
HO OH
B2 Bi(2’,4’-dihydroxy-α- N N
methylbenzylidene) –diimine
双(2’,4’-二羟基-α-甲基苄基)-乙 二亚胺
HO OH
HO OH
B3 Bi(2’,4’-dihydroxy-α-methylbenzyl- N N
idene)-ethylenediimine
双(2’,4’-二羟基-α-甲基苄基)-1,3-
丙二亚胺
HO OH
HO OH
B4 Bi(2’,4’-dihydroxy-α-methylbenzyl-
idene)-1,3-trimethylenediimine
5-甲氧基-2-[1-(丙亚胺基)乙基]
苯酚
P1
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