低氧运动对大鼠血脂代谢的影响-运动人体科学专业论文.docx

广州 广州体育学院 2006 届硕士研究生学位（毕业）论文 低氧 低氧运动对大鼠血脂代谢的影响 PAGE PAGE 10 PAGE PAGE 13 和 HDL-C 水平、LPL 活性上升都更明显，其中 LDL-C 的水平下降有显著性差异 （P＜0.05）；低住高练组 LDL-C 水平与常氧运动组有极显著性差异（P＜0.01）， 低住高练组的 HDL-C 水平、骨骼肌 LPL 活性都与常氧运动组有显著性差异（P＜ 0.05）；高住高练组肝脂酶活性与常氧运动组有显著性差异（P＜0.05），但是与 其它低训组之间并无显著性差异，血清胰岛素浓度与常氧安静组有显著性差异（P ＜0.05）。 结论： （1）低氧条件有利于血脂代谢的改善，但是单纯低氧刺激的作用非常有限。 （2）低氧运动通过两种负荷协同作用，其改善血脂代谢的效果更为明显，特别 是低住高练组 HDL-C 和 LDL-C 水平的变化最为明显并与常氧运动组有显著性差 异。从改善血脂代谢来看，低氧运动尤其是低住高练这种训练方法比常氧运动更 为有效。 （3）低氧运动大大提高了骨骼肌脂蛋白脂肪酶的活性，大大增加了脂肪酸的利 用率，使血脂成分发生有益变化。这是低氧运动组改善血脂代谢效果优于其它组 的重要原因。从低住高练组骨骼肌脂蛋白脂肪酶活性比常氧运动更明显提高就可 以看出，低氧条件下运动后在常氧状态下恢复对骨骼肌有氧代谢能力的增强更为 有利。 （4）低氧运动使骨骼肌脂蛋白脂肪酶活性提高并引起肝脂酶活性的降低 都反映 出骨骼肌和其他外周组织对胰岛素的敏感性提高了，血清胰岛素水平的降低也证 实了这一点。它提示了通过低氧健身运动防治 II 型糖尿病的可能性。 关键词：低氧运动；血脂代谢；甘油三酯；胆固醇；脂蛋白脂肪酶；胰岛素 HOW HYPOXIC EXERCISE AFFECT THE RATS ON BLOOD LIPID METABOLISM Abstract In order to explore inner mechanism on how different hypoxic exercise affect blood lipid metabolism, healthy rats were selected as the object of the study. This research was designed on the basis of relevant research of internal and external experts, combining with optimum hypoxic condition which can improve oxidative ability much better. The index as body weight(BW), the ratio of fat weight(FR), triglyceride(TG), high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol（LDL-C）, total cholesterol（TC）, lipoprotein lipase(LPL), hepatic lipase(HL), insulin level was chosen to find the effect of hypoxic exercise to them and also the relationship between them. 52 male SD rats of 8 weeks old were randomly divided into 6 groups as following: Normoxic control group, Normoxic exercise group, Hypoxic control group, living high-training high, living high-training low, living low-training high.. The hypoxic chamber imitated hypoxic and normobaric condition, oxygen concentration inside was controlled at 15.3%, which is equal to 2500m high altitude. The speed of normoxic treadmill is 25m/min.The speed of hypoxic treadmill is 20m/min. Exercise groups