环糊精及其衍生物与丹参酮Ⅱa超分子包合作用的研究-无机化学专业论文.docxVIP

环糊精及其衍生物与丹参酮llA超分予包含作用的研究的包合行为。并用分子模拟的方法作了进一步的确证。热动力学法研究 环糊精及其衍生物与丹参酮llA超分予包含作用的研究 的包合行为。并用分子模拟的方法作了进一步的确证。热动力学法研究 了温度对包合反应的影响，测得了有关热力学参数，从而探讨了包合过 程可能的包合机制，揭示了反应的驱动力。 3、采用荧光光谱，红外光谱等光谱法研究了Y—CD与Tan IIA的包 合行为。并用分子模拟的方法作了进一步的确证。热动力学法研究了温 度对包合反应的影响，测得了有关热力学参数，从而探讨了包合过程可 能的包合机制，揭示了包合反应的驱动力。并对B-CD和Y—CD两种环 糊精的包合行为进行了比较。 关键词：环糊精；丹参酮IIA；包合物：热动力学；分子模拟 ———————————————————————————————————————————————————一 ———————————————————————————————————————————————————一垒坠!坠垒翌 ～—一 ABSTRACT Cvclodextrins(CDs)are natural cyclic oligosaccnarides，consisting ot 6～1 2 glucose unite Linked by Q一1，4-glycosidic bond，a hollow truncated cone structure．The unique structures allow a variety of guest molecules to be accommodated in the hydrophobic cavities to form host—guest inclusion complexes and chang their physical，chemical and biological properities·So CDs have been used widely in pharmacy eutical industry，rood， environlnental conservation，cosmetics，etc．Especially in pharmaceutical industrv，CDs are able．to be used to improve solubility，stability，stripping speed as weli as biological using of drugs．Today，onle a-，D一，y-C．D with 6-8 glucose unites are widely used． Dan—shen，an ancient Chinese drug，is a kind of plant root，which is one of labiate salvia family．It can mainly stimulate circulation to end stasis and diminish inflammation．So various preparation of Dan—shen is abroadly applicated to all kinds of clinic diseases，such as cardiovascular disease，hepatitis，department of inj ured，department of dermatology and lose one，S hair etc．It is especial on coronary heart disease．People in medical field attach importrance on Dan—shen．The fatsduble active principle of Dan—shen i s tanskinone IIA(Tan IIA)．which is a o—quinone framwork．As a resuct，copplication and effect exertion of Tan IIA is largly restricted because of its dissolubicity．We must improve its solubility and stabidity． Cyclodextrin(CD)is a compand of solubility and is stable under alkali，heat and light．As supplementary materals of drug，CD can improve