环糊精和杯芳烃的包合特性及其在药物中的应用-药物分析专业论文.docxVIP

摘要 摘要 烃的荧光具有猝灭的特性，建立了一种高灵敏测定8一胡萝卜素的新方法。 关键词： 环糊精：杯芳烃；包合作用；包合物；药物 VII 垒堕!型 垒堕!型 一一一 Abstract Chapter l：The recent development of cyclodextrins and calixarenes has been reviewed，especially its development in drug delivery system．At the same time，the application of the cyclodextrins and calixarenes on carotenoids was expatiated． Chapter 2：The interaction of Piroxicam with sulfobutylether-13-cyclodextrin (SBE一13．CD)was compared with that of hydroxypropyl—p—cyclodextrin rHP．13一CD)．The stability constants of the inclusion complexes were obtained by steady．state fluorescence technique．Experimental conditions including concentrations of the two cyclodextrins and media acidity were investigated for the inclusion formation in detail．The results suggested that the interaction of Piroxicam with charged CD(SBE-D-CD)is much stronger than that with neutral CD(HP—D—CD)at any pH studied，in terms of a synergetic effect of hydrophobic and electrostatic interactions， Chapter 3：Water-soluble inclusion compounds of 13-cyclodextrin with 13-carotene were prepared by two methods：(1)complexmion in solution and (2)complexation by kneading．It WaS found that UV-Vis absorption spectra of the inclusion compounds in water were dilyerent from those of 3-carotene in water-miscible organic solvents(DMF)and 13-cyclodextrin in water,which confirmed the formation of the inclusion compounds．Specific interaction of 13-carotene and 13-cyclodextrin caused great changes in absorbance maximum of 13-carotene．It is considered that in water the hydrophobic moiety (13一carotene)of such inclusion complexes should tend to self-associate forming large supramolecular aggregates． Chapter 4：Inclusion compounds of 13-carotene with CDs including 13-CD， HP—p—CD and SBE—p—CD had been prepared by using improved method and Abstractcharacterized Abstract characterized via UV-Vis absorption spectroscopy,1R spectra and H NMR technique．The solubilization and stabilization of inclusion compounds were investigated in detail．Ex