IGF1在大鼠肝纤维化过程中的态变化及扶正化瘀方对肝纤维化的影响.docx

/ 舢!I{|l㈣川ll|111111I|!I 舢!I{|l㈣川ll|111111I|!I I!111唧 目 录 Y1 9008 1 3 中文摘要 1 英文摘要 5 研究论文IGF．1在大鼠肝纤维化过程中的动态变化及扶正化瘀方对肝 纤维化的影响 引言 ··· ········· ··· ··· ··· ··· ···12 第一部分IGF。1在实验性大鼠肝纤维化自发逆转过程中的动态变化 前言月IJ舌 “””一“””“ “”””““””一”““””“”“”“”“··· ”” “一1414 材料与方法 14 结果 · -·· ··· ········· ·· ········· · ········ ··· 18 附图 ······ ············· · ······· ··· ···· ········ ·········22 附表···· ·····················································-······· ····33 讨论···························· ·········· ······· ·········· ········35 刀、结 ································································ ·····39 参考文献 39 第二部分扶正化瘀方对实验性肝纤维化及肝组织IGF．1的影响 前言目lJ吾 ”””““””””””””” ”“”””””“”””一”“一一 ”“”一’42···42 材料与方法 42 结果 ························ ········ · ····· ···· ··．43 附图 ··········· ·········· ······ ·······································46 附表 ··· --·51 讨论···········································································53 小结 ······ ········-········· ······ ······ ···56 参考文献 56 结论 ········ · ··-······ ········ · ············ ··· ···58 综述胰岛素样生长因子．1在肝脏疾病中的研究 59 致谢················· ···················· ············· ······ ·············71 个人简历 72 / 中文摘要IGF．1在大鼠肝纤维化过程中的动态变化及扶正化瘀方 中文摘要 IGF．1在大鼠肝纤维化过程中的动态变化及扶正化瘀方 对肝纤维化的影响 摘 要 目的：肝纤维化(hepatic肋rosis)是各种致病因素引起肝细胞损伤，继 发肝脏炎症及肝组织自我修复的一个复杂的病理过程。该过程致使细胞外 基质(extracellular matrix，ECM)合成和降解失衡，从而引起ECM在肝组织 内过度沉积形成肝纤维化，甚则肝硬化。在肝纤维化形成的过程中，细胞 因子起了关键性的作用。肝星状细胞(h印atic stellate cell，HSC)是分泌各种 细胞因子和产生ECM的主要细胞，HSC的激活、增殖是肝纤维化形成的 关键环节。在HSC增殖、活化及合成ECM的肝纤维化过程中，多种细胞 因子如转化生长因子B 1(transfoming gro、Vth facto卜B l，TGF．B 1)、胰岛素 样生长因子．1(insulin．1ike gro、他factor．1，IGF．1)