HMGB1等不细胞黏附因子在不同类型乳腺癌组织中的表达及意义.docx

HMGB-1等不同细胞黏附因子在不同类型乳腺癌 HMGB-1等不同细胞黏附因子在不同类型乳腺癌 组织中的表达及意义 中文摘要 目的 通过观察不同类型乳腺癌组织中相关细胞因子及受体的表达，探讨乳腺癌转 移的分子生物学机制，为临床制定乳腺癌个性化治疗方案提供依据。 方法 取临床病理诊断证实的不同类型乳腺癌40例(其中小叶型、导管型、髓样 癌和派杰氏病各10例)，应用免疫组织化学的方法， 观察HMGB．1、VCAM—l 以及相关受体CXCR4在前述不同类型乳腺癌组织中的表达，并利用图像分析比 较光吸收密度的差异。 结果 各组类型乳腺癌组织细胞HMGB．1、VCAM．1以及相关受体CXCR4均有表 达，但表达强度派杰氏病、髓样癌、小叶型至导管型依次增加，差异有显著性。 结论 l、各组类型乳腺癌组织细胞HMGB．1、VCAM．1以及相关受体CXCR4均 有表达。 2、HMGB．1、VCAM．1以及相关受体CXCR4的表达强度，小叶型、导管 型、派杰氏病至髓样癌依次增加，差异有显著性。 3、细胞黏附分子HMGB．1、VCAM．1以及相关受体CXCR4表达与不同类 型乳腺癌组织浸润性生长及转移发生概率有直接的相关性。 研究生：李军霞(人体解剖与组织胚胎学) 导师：夏玉军 关键词 乳腺癌、浸润性、转移、HMGB．1、VCAM．1、CXCR4 ＼嘲Y删2042936Expression ＼嘲Y删2042936 Expression of HMGB-1，VCAM-1 and CXCR4 in Different Types Cancer Tissue of Brest GIand Abstract Purpose 111is paper aims to discuss the approaches concerned in breast canceT met嬲tasis and its morbidity mechanism by observing the expression of cell adhesion factors (CAF)such as the HMGB·1 and VCAM一1 and that of the related receptor CXCR4 in different kinds of breast CanCer tissues． Method： 40 cases of different types of breast CanCer,confirmed by clinical pathology diagnosis，were sampled，of which 1 0 cases were microphyll type，10 vessel type，10 encephaloid cancer,and 10 Paget‘§disease．ne method of iIll删m出咖ch锄is时 was applied to the analysis of the 40 Cases，measuring the expression of the HMGB一1 and VCAM·1 and that of the related receptor CXCR4．A comparison was made between the differences in absorbency through the analysis of the pictures． Result Expressions of breast CanCer histiocyte such as the HMGB-l andVCAM一1 and that of the related receptor CXCR4 were found common in the four type mentioned above．However,the expressions were found increasing from Paget‘S disease，to encephaloid CanCer，to mierophyll type and to vessel type． Conclusion The difference in the probability of tissue infiltrative growth and occuncnce of metastasis in various kinds ofbreast cancer has something to do wim the cell adhesion factors(CAF)in the CanCer histiocyte，such as the HMGB-l and VCAM·l and