ID调控Th17Treg分化在哮喘免疫耐受中的作用研究.docx

第三军医大学硕士学位论文缩略语表 第三军医大学硕士学位论文 缩略语表 英文缩写 英文全称 中文译名 IDO indoleamine 2，3 dioxygenase 吲哚胺2，3双加氧酶 Treg regulatory T cell 调节性T细胞 Th helper T lymphocyte 辅助性T细胞 D翰 ovalbumin 鸡卵白蛋白 BLAF bronchoalveolar lavage fluid 支气管肺泡灌洗液 EOS eosinocyte 嗜酸性粒细胞 AHR airway hyper—responsiveness 气道高反应性 IL一4 interleukin．4 白介素4 IL．5 interleukin．5 白介素5 IL．10 interleukin．10 白介素lO IL．17 interleukin．17 白介素17 TGF-p transforming growth factor 转化生长因子p IFN吖 interferon—y 干扰素丫 Foxp3 forkhead／winged．helix 3 叉头状螺旋转录调节因子 RORrt retinoid．related orphan receptor竹 维甲酸相关孤儿核受体丫t SIT allergen-specific immunotherapy 变应原特异性免疫治疗 CTLA．4 cytotoxic T lymphocyte antigen一4 淋巴细胞相关抗原 iTreg inducible Treg 可诱导调节性T细胞 DC dendritic cell 树突状细胞 pDC plasmacytoid dendritic cell 类浆细胞样树突状细胞 mDC myeloid dendritic cell 髓样树突状细胞 1．MT 1-methyl．DL．tryptophan 1-甲基色氨酸 PBS phosphate buffer saline 磷酸盐缓冲液 HE hematoxylin and eosin staining 苏木素．伊红染色 FCS fetal calf serum 胎牛血清 ELISA Enzyme．Linked Immune Sorbent Assay 酶联免疫吸附实验 HPLC high performance liquid chromatography 高效液相色谱法 万方数据 第三军医大学硕士学位论文The 第三军医大学硕士学位论文 The study of the role of IDO regulation the differentiation of Thl 7／Treg in the immune tolerance of asthma Abstract Background： Asthma is a serious global heakh problem affecting all age groups．The prevalence of asthma is increasing in many countries，especially among children．Research has suggested that the prevalence of asthma increased dramatically approximately 50％per 1 0 years in childhood asthma in the last twenty years．The global cost has increased by 30％for the control of abrupt deterioration and daily symptoms in the asthma patients，and it has brought significant impact on people’S work，studies and lives．Therefore，it is of great practical significance to carry out the research of asthma control and prevention． The mainstay treatment for asthma is inhaled corticosteroids，but inhaled corticosteroids can only control asthma not cure asthma．The World Heakh Organization(WHO)and the European Academy of Allergy and Clinical Immunology(EAACI)r