HFHG45基因对血液与血管标基因表达的影响-遗传学专业毕业论文.docx

ABSTRACTMammal ABSTRACT Mammal life cycle is longer,which often leads to gene knockout totally embryonic lethality is not conducive to the cardiovascular system research and observation．Zebrafish small size，can provide oxygen and nutrients by osmosis，even if there are serious cardiovascular defects can survive for some time．Its embryonic transparent，easy to detect and observe the process of cardiac development in zebrafish and humans are highly evolufionarilyevolutlonarfly conserved,it’conserved,it lS one ofof the‘dealthe ideal modelmode l scholars recognized research and development of biological heart and cardiovascular．Our previous discovery HFHG45 regulation of blood and blood vessel development．In this paper,the model organism zebrafish gene HFHG4 5 further study the impact on the hematopoiefic system development．According to reports，the number of incidence of cardiovascular and cerebrovascular diseases r龇Llf$first major country,but most of our mortality diseases．ne occurrence and development of many human diseases are associated with the development of blood vessels or have a very close and inextricably linked． Vertebrates and blood vessels are derived from the sRme cell that progenitor cells of the blood．Blood progenitor cells originated in the mesoderm，and then differentiate into vascular progenitor cells and blood progenitor cells．By the blood progenitor cells from the blood cells mainly involved in the early pre-hematopoietic progenitor cells deriVed from the blood of the regulation of hematopoietic stem cells，differentiate into mature myeloid cells，red blood cells and lymphocytes．Vascular progenitor cells begin to differentiate into vascular endothelial(EC)cell， aRer differentiation of arteries，veins and lymph vessels and the like． Blood vessels and the development process iS under the contr01 of m 万方数据 complex complex and orderly conduct of the molecular signaling networks，which C锄cause senous abnormal developmental detects or serious illnesses． 一