红霉素治疗毛细支气管炎15例临床疗效观察+rsv毛细支气管炎继发哮喘机制的初步探讨-儿科学专业论文.docxVIP

遵义医学院2003级硕士研究生论文红霉素治疗毛细支气管炎15例临床疗效观察 遵义医学院2003级硕士研究生论文 红霉素治疗毛细支气管炎15例临床疗效观察 中文文摘 [目的]评价静脉输注红霉素治疗毛细支气管炎的l摘床效果，同时探讨红 霉素治疗毛细支气管炎的机制。 [方法]对2004年9月至12月在遵义医学院附属医院儿科收治的经过常 规治疗及静脉输注激素治疗效果欠佳的15例毛细支气管炎患者， 在原有的基础上加用红霉素治疗，并观察其临床症状及体征变化。 [结果llS例患儿的肺部哮鸣音于加用红霉素治疗平均2．6天后完全消失， 咳喘症状也随之消失。1例患儿的肺部哮鸣音于加用红霉素治疗1 天后即消失：另外14例患儿的肺部哮鸣音均于加用红霉素治疗l 天后明显减轻，于加用红霉素2～4天后完全消失。15例患儿均未 出现恶心、呕吐及肝脏损害等与红霉素治疗相关的不良反应。 [结论]红霉素可能从纠正Thll Th2细胞失衡、抑制气道上皮细胞粘液 过量分泌及降低气道高反应性三个方面影响了毛细支气管炎患 者病理生理的发展过程，从而影响了毛细支气管炎患者的症状及 体征。所以，红霉素是治疗毛细支气管炎效果较好的药物。 [关键词]毛细支气管炎；红霉素：药物疗法 第3页共26页 遵义医学院2003级硕士研究生论文Clinical 遵义医学院2003级硕士研究生论文 Clinical Efficacy of Erythromycin Therapy in the 15 Infants with Bronchiolitis ABSTRACT 【obieefivel To observe the clinical efficacy of erythromycin therapy in the infants with bronchiolitis，and to explore the possible mechanism of erythromycin treatment in infants with bronchiolitis． 【MethodsJ 1 5 infants with bronchiolitis were included in this study．Before this study，they had been treated with conventional treatment and intravenous glucocorticoid therapy，but the clinical signs and symptoms had been not well improved．Intravenous administration of erythromycin was followed，and changes in the clinical signs and symptoms were also observed． 【Resultsl Wheezing in 1 5 infants disappeared at mean 2．6 days after erythromycin therapy,and the eoughing symptom also disappeared at the same time．One infant’s wheezing disappeared completely after one day of erythromycin therapy，while others’wheezing was significantly reduced after one day of erythromycin therapy and disappeared after 2—4 days of erythromycin therapy．Any adverse effects associated with erythromyein，such as nausea，vomit and liver damage，were not found． IConclusionl Erythromycin can improve the clinical signs and symptoms of b南nchiolitis by correcting the Th 1／Th2 imbalance．inhibiting the mucus hypersecretion and reducing the degree of airway hyperresponsiveness． Therefore，erythromycin is an effective medicine for bronchiolitis． 【Key wordsJ Bro