COMT基因、心理因素、急性术后痛之间的关系-麻醉科专业毕业论文.docx

硕士学位论文 硕士学位论文 英文摘要 AB STRACT Obj ecfive The present study investigated the relationships among the catechol—O—methytranserase(COMT) gene polymorphisms 、psychological factors，including anxiety、depression、personality,acute post—operative pain and the efficacy of fentanly。 Methods Ninety ASA I‘_——III inpatiens undergoing abdominal elective surgery between 20 and 75 yeas old completed the Self-Rating Depression Scale(SDS) inventory、the State—Trait Anxiety Inventory(STAI)and Eysenck Personality Questionaire(EPQ)inventory before the day of surgery．Standard intravenous general anesthesia、surgery and intravenous patient-controlled analgesia(W-PCA) was conducted．Postoperative ratings ofpain intensity，opiod consumption、number ofPCA injections and demands、blood pressure、heart rate and saturation ofblood oxygen were recorded after surgery on the ward。The degree of pain intensity was evaluated by a visual analogue scale(VAS，1-1 0)．For COMT genotyping，4 ml of venous blood from each subj ect was collected． Results The pain intensity,total analgesic consumption in 24h and4 8h were signicantly related to preoperative trait-anxity,．state—anxity and depression ①=O．000，0．00 1)．Fentanly consumption in 48h was signicantly related to age(p=O．01 8，0．008)．But theCOMT Vall 58Met polymorphisms did not show association with opiod consumption and psychological factors． Conclusions The psychological factors were signicantly associated with pain intensity and total analgesic consumption after surgery． Key words pain gene COMTgene psychology anxiety depression personality II 硕十学位论文 硕十学位论文 缩略词 中英文缩略语对照表 APS average pain sensitivity 中度疼痛敏感性 COMT catechol—O—methytranserase 儿茶酚氧位甲基转移酶 EPQ Eysenck Personality Questionaire 艾森克个性问卷 HA harm avoidance 躲避伤害型 HPS 11igh pain sensitivity 高度疼痛敏感性 LPS low pain sensitivity 低度疼痛敏感性 NS novelty seeking 寻求刺激型 ORF open reading frame 开放性阅读框架 P