抗生素骨水泥骨感染.pdfVIP

Neurosurg Rev (2009) 32:485–490 DOI 10.1007/s10143-009-0209-1 ORIGINAL ARTICLE A novel canine model of acute pyogenic spondylodiscitis Wei-Hua Chen Lei-Sheng Jiang Li-Yang Dai Received: 6 August 2008 /Revised: 18 January 2009 / Accepted: 14 April 2009 /Published online: 15 July 2009 # Springer-Verlag 2009 Abstract New, appropriate in vivo animal models are Keywords Spondylodiscitis . Spinal infection . needed for the study of the pathogenesis of spinal infections Animal model . Canine . Staphylococcus aureus and the development of novel anti-infection strategies. The purpose of this study was to develop a canine model of acute pyogenic spondylodiscitis which can best mimic the Introduction human spinal infection process, characterized by separately inoculating bacterial suspension into the lumbar interverte- Pyogenic infection of the spine is an uncommon, but not bral spaces of a single animal. A total of 14 dogs were used rare, clinical problem. In recent years, the incidence of in this study. An inoculation containing Staphylococcus spinal infections has appeared to increase, which may be aureus and sodium morrhuate was injected into the attributable to various factors such as the aging of the intervertebral spaces. Two pilot studies were carried out to society, the abuse of intravenous drugs, the widespread use determine the most appropriate concentration of the of immunosuppressive therapy for organ implant recipients, bacterium inoculum. Before the inoculation, the interverte- and the progress in diagnostic methods with higher bral disks were partially removed and the end plates of the specificity [2]. These diseases often affect the “at-risk” adjacent two vertebrae were deliberately curetted out to populat