神经影像学新进展在神经外科中应用.pptVIP

* SWI 对微出血灶的显示比梯度回波序列(GRE)敏感3~6倍 巨大的脂质中心通常是斑块的主要成分， 脆性，细胞凋亡；蛋白酶，细胞因子，分泌 易损斑块 易损斑块 mI与（慢性病灶）胶质增生有关，随着星形细胞瘤恶性度增加而增高（星形细胞的标志物）；Lip多出现于肿瘤坏死灶内 * * jianbianxing * 图6．鼠脑放射性坏死和胶质瘤的钆剂增强和APT磁共振像的比较。（a）放射性坏死（40Gy；照射后178天；绿色实线箭头）作为揭示的Gd增强。(b)SF188/V+人脑胶质瘤（植入后16天；开放的粉红色箭头）。(c)9L胶质瘤（植入后11天；开放的红色箭头）。(d)APT图像强度的定量比较（水信号强度的百分数）。放射性坏死和肿瘤有相反的APT信号强度。 Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, et. al. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Medicine 17, 130-134 (2011). * * What did we achieve ? we could acquire simultaneously with both modalities. The PET images were of very high quality, klick and the MR images were fine as well. The superposition will give the intended information gain! 2mm clearly resolved in the dorenzo ? Phantom PET - 19 steps of rotation (~180 degrees), 6-20 min count time per step, 8.5 ns time window, custom OSEM reconstruction?? (maybe Larry can give us info here); MR - 106 seconds spin echo sequence, 104 seconds 2D gradient echo sequence, 124 seconds 3D gradient echo sequence per rotational step, the MR slice thickness, voxel size??, etc... I think the MR people will want to hear about your sequences and things they can relate to easier. 新技术 很有潜力 * What did we achieve ? we could acquire simultaneously with both modalities. The PET images were of very high quality, klick and the MR images were fine as well. The superposition will give the intended information gain! 2mm clearly resolved in the dorenzo ? Phantom PET - 19 steps of rotation (~180 degrees), 6-20 min count time per step, 8.5 ns time window, custom OSEM reconstruction?? (maybe Larry can give us info here); MR - 106 seconds spin echo sequence, 104 seconds 2D gradient echo sequence, 124 seconds 3D gradient echo sequence per rotational step, the MR slice thickness, voxel size??, etc... I think the MR people will want to hear about your sequences and things they can relate to easier. 新技术 很有潜力