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FDA
Anesthetic Life Support Drugs
Advisory Committee
Sept. 10, 2003;Susstained-release hydromorphone
(Palladone)
--Risks vs. benefits discussion;Benefits
Review
sustained release opioids vs.
IR opioids; IR oxycodone vs CR oxycodone
Comparable
Efficacy Safety
Hale Clin J Pain 9/99 BACK PAIN
Kaplan R J Clin Oncol 10/98 CANCER
Stambauugh J.Clin Pharm 5/01 CANCER
;OxyContin--NDA--1995;OxyContin---NDA---1995
Summary of Efficacy
“CR oxycodone appears to be a BID alternative
to conventional QID oxycodone. Approval is recommended. Care should be taken to limit competitive promotion. This product has been shown to be as good as current therapy, but has not been shown to have a significant advantage beyond reduction in frequency of dosing.”
--Curtis Wright, MRO
;The Medical Letter—9/17/01
“OxyContin is a q12h controlled-release formulation of oxycodone that can be used effectively in the treatment of pain due to cancer, and occasionally, other types of chronic pain. There is no evidence that oxycodone offers any advantage over appropriate doses of other opioids, and it appears to have the same potential for addiction as morphine.”;CR morphine vs CR oxycodone
Comparable in
Efficacy and Safety
Heiskanen Pain 10/97 CANCER
Mucci-LoRusso ’98 CANCER
Bruera J. Clin Oncol 10/98 CANCER; IR hydromorphone vs
CR hydromorphone (Q12hr)
Comparable
Efficacy and Safety
Hayes Cancer 9/94 CANCER
Bruera J. Clin Oncol 5/96 CANCER;CR oxycodone vs CR hydromorphone
(Q12hrs)
Comparable
Efficacy Safety
Hagen Cancer 4/97 CANCER;Summary
1. IR opioids and SR opioids are
comparable in efficacy safety
2. SR preparations appear comparable in efficacy safety;Benefits:
---CONVENIENCE
of bid or qd dosing
---Convenience of less pills
---for patients intolerant to other
opioid preparations;Risks of sustained release
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