Atherosclerosis动脉粥样硬化.pdfVIP

Atherosclerosis and Coronary Heart Disease Dept. of Cardiology Dept. of Cardiology Tongji Hospital Tongji Hospital Prof. Xiaomei Guo Prof. Xiaomei Guo xmguo @ tjh.tjmu.edu.cn xmguo @ tjh.tjmu.edu.cn Atherosclerosis Coronary Heart Disease Atherosclerosis Definition Independent risk factors Pathophysiology Coronary Heart Disease Definition Asymptomatic state (subclinical phase) angina pectoris Acute MI STRUCTURE OF THE NORMAL ARTERY (1) The Intima: The endothelial cell of the arterial intima constitutes the crucial contact surface with blood. (2) The Tunica Media: have well-developed concentric layers of smooth muscle cells (3) The Adventitia: contains collagen fibrils in a looser array than usually encountered in the intima. Vasa vasorum and nerve endings localize in this outermost layer of the arterial wall. atherosclerosis The word atherosclerosis is of Greek origin and literally means focal accumulation of lipid (ie, athere [gruel]) and thickening of arterial intima . atherosclerosis refers to the presence of atherosclerotic changes within the walls of the arteries, which causes impairment or obstruction of normal blood flow with resultant organ ischemia. Pathophysiology Atherosclerosis is a progressive disease process that generally begins in childhood and manifests clinically in mid-to-late adulthood. The distribution of lipid and connective tissue in the atherosclerotic lesions determines whether they are stable or at risk of rupture, thrombosis, and clinical sequelae. Different stages of atherosclerotic plaque Different stages of atherosclerotic plaque development development 炎症标记物