MRSA肺炎诊治进展.pptVIP

* In our examination of 201 patients with acute MRSA 我们检查了201例急性MRSA肺炎患者 pneumonia and 164 patients with acute MSSA pneumonia, 164例MSSA患者 The mean age of the patients with MRSA was higher MRSA平均年龄高于MSSA感染患者 than that of patients with MSSA (Table 1). The proportion of nosocomial infection was significantly higher in MRSA院内感染比例显著高于MSSA patients with MRSA than those with MSSA (p,0.001). With respect to underlying diseases, the frequencies MRSA感染患者中：心血管疾病、恶心肿瘤、糖尿病比例高于MSSA感染患者。 of cardiovascular diseases (n560, 88.2%), malignancy (n539, 57.4%) and diabetes mellitus (n523, 33.8%) in patients with MRSA were significantly higher than those in patients with MSSA (p,0.001, p,0.001, and p50.005, respectively). The most frequent presenting symptom in patients MRSA肺炎最常见的体征是咳嗽、94.1%、发热80.9%、痰73.5%。 with acute MRSA pneumonia was cough (n564, 94.1%), followed by fever (n555, 80.9%) and sputum (n550, 73.5%). The frequencies of sputum and dyspnoea were significantly higher in cases of MRSA than MSSA MRSA痰和呼吸困难的频率显著高于MSSA. (p,0.001 and p50.042, respectively). * * * * Methods. To compare the safety and efficacy of linezolid and vancomycin in febrile, neutropenic patients with cancer, we conducted a double-blind, multicenter equivalence study. Eligible patients with proven or suspected infection due to a gram-positive pathogen were randomized to receive linezolid or vancomycin 为了对比利奈唑胺和万古霉素在粒缺伴发热的肿瘤患者中的安全性和疗效，我们进行了双盲、多中心等值研究。合格的确诊或者怀疑阳性菌感染随机分组接受利奈唑胺或万古霉素。 * * * * 使用6周龄雌性BALB/c小鼠。 鼻腔接种MRSA悬液(30μl/小鼠；约 106 至107 CFU/小鼠)后，立即皮下注射利奈唑(0.4 mg/小鼠；12 mg/kg 体重) 或万古霉素（1 mg/小鼠； 40 mg/kg) ，分别于MRSA感染后2小时、6小时获得小鼠肺组织，进行细菌数测定。 * * * * 采用不同LZD剂量来评价抗炎作用。 * * 使用1/2, 1/4, 和1/8 LZD亚抑菌(sub-MIC)浓度溶液来检测毒力因子表达是否能被LZD抑制。亚抑菌浓度LZD溶液加入MRSA菌液过夜震荡培养。过夜培养菌液使用0.22μm孔径滤器过滤后给小鼠皮下注射。为检测抗菌药物对宿主介导免疫反应的可能抑制作用，其中一组LZD在滤器过滤除菌的MRSA菌液给药前1h给药。 * * 使用1/2, 1/4, 和1/8 LZD亚抑菌(sub-MIC)浓度溶液来检测毒力因子表达是否能被LZD抑制。亚抑菌浓度LZD溶液加入MRSA菌液过夜震荡培养。过夜培养菌液使用0.22μm孔径滤器过滤后给小鼠皮下注射。为检测抗菌药物对宿主介导免疫反应的可能抑制作用，其中一组LZD在滤器过滤除菌的MRSA菌液给药