中国斑马鱼研究发展历程及现状-中国管理科学.PDFVIP

HEREDITAS (Beijing) 2012 9 , 34(9): 1082―1088 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2012.01082 中国斑马鱼研究发展历程及现状 贾顺姬, 孟安明 , 100084 斑马鱼作为重要的脊椎动物模式系统之一, 由于其多方面的优势, 在生命科学研究领域发挥着越来越重 要的作用。目前, 斑马鱼已被广泛地用于发育生物学、分子生物学、细胞生物学、遗传学、神经生物学、肿瘤 学、免疫学、海洋生物学、药物学、毒理与环保等诸多方面的研究, 一些重要的成果不断涌现, 为现代生命科 学的发展做出了重要贡献。我国20 世纪90 年代后期引入斑马鱼模式系统, 此后研究队伍扩大很快, 有影响的 研究成果不断涌现, 促进了多个学科的发展。文章重点综述了我国内地与香港地区在斑马鱼研究方面的发展历 程以及所取得的代表性成果, 以期促进该模式系统更广泛地用于开展高水平研究。 斑马鱼; 模式动物; 生命科学 The development of zebrafish research in China JIA Shun-Ji, MENG An-Ming School of Life Sciences, Tsinghua University, Beijing 100084, China Abstract: As one of the most important vertebrate model systems, the zebrafish plays increasingly important roles in the field of life sciences. At present, zebrafish is widely used in studies on developmental biology, molecular biology, cell biology, genetics, neurobiology, oncology, immunology, marine biology, pharmacology, toxicology, and environmental protection. The zebrafish-based studies have led to many important discoveries that contribute to the development of modern life sciences. The zebrafish model system was introduced into China in the late 1990s; since then, the Chinese zebrafish community has being expanded fast with more influencing research outcomes, promoting a wide range of disciplines. This review gives an overview of zebrafish-based studies and representative findings in the mainland and Hong Kang of China, aiming to promote wider utilization of zebrafish for high-level studies. Keywords: zebrafish; model animals; life sciences 1