exosome 外泌体在肿瘤转移中的作用.pptx

The role of exosomes in cancer metastasis外泌体在肿瘤转移中的作用;Exosome;Morphology;biogenesis;;Exosomal content;;Biological functions and effects;外泌体的临床应用 ;肿瘤转移;1. exosomes as mediators in EMT;EMT and migration;2. Exosome and invasion ;;Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype;3.Exosomes and CAFs ;CAFs produce exosomes, which stimulate the Wnt-pathway in breast cancer cells and enhance their migratory capabilities ;4.Engraftment of metastatic cells;5. Exosomes in organotropic metastatic growth;;M.Y. Fong, W. Zhou, L. Liu, A.Y. Alontaga, M. Chandra, J. Ashby, et al.,Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis, Nat. Cell Biol. 17 (2) (2015)183–194.;;7.Immune-modulating effects of exosomes ;A central event involves an aberrant expression of COX-2 which influences cell-cycle progression and contribute to the acquisition of a cell migratory phenotype through the induction of epithelial mesenchymal transition genes and down-regulation of E-cadherin expression. The identification of novel molecular determinants involved in the cross-talk between platelets and cancer cells has led to identify novel targets for anti-cancer drug development.;;TDEs and cellular immune response ;;TDEs and humoral immune response;TDEs and cancer-promoting proinflammatory effects;总结