临床医生科研之路.pptx

临床医生的科研之路;目 录;科学研究的分类;Basic research is performed without thought of practical ends. It results in general knowledge and an understanding of nature and its laws. This general knowledge provides the means of answering a large number of important practical problems, though it may not give a complete specific answer to any one of them. The function of applied research is to provide such complete answers.;(1) Patient-oriented research. Research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects. Excluded from this definition are in vitro studies that utilize human tissues that cannot be linked to a living individual. Patient-oriented research includes: (a) mechanisms of human disease, (b) therapeutic interventions, (c) Clinical trials, or (d) development of new technologies. (2) Epidemiologic and behavioral studies. (3) Outcomes research and health services research.;转化研究的定义-NIH;临床转化研究; Clinical Practice Cost and Reimbursement FDA Industry Clinical Problem FDA IRB Clinical Research Basic Research ;※国家重大基础研究发展项目（973）：重大科学前沿问题与国民经济发展的重大需求（人口与健康） 973前期项目（国家“八五”、“九五”攀登计划的延续）； ※ “863”国家高科技攻关项目；;※“十五”国家科技攻关项目；‘十二五’支撑计划 ※国家自然科学基金资助项目：基础及应用基础研究，鼓励原始创新；　 重大项目、重点项目、面上项目、青年基金、地方基金、国际合作基金、港澳合作基金、杰出青年基金、优秀青年基金、研究团队（群体）基金、主任基金； ※教育部、卫生部、省市地方基金。;基金资助的基本格局;临床医师科研工作中的困惑;临床医师科研工作中的优势;医生科学家（Physician-Scientist）;Stages of a Clinical Research Study;临床研究过程及其阶段;临床研究顶层设计-在文献中找选题;临床研究顶层设计-临床问题-文献复习;临床研究顶层设计-临床问题-科学问题;中华医学会慢性呼吸道疾病科研专项资金（07010360044）;中国COPD患者不同性别对疾病的认知与治疗差别的 多中心研究;COPDgene研究中无症状COPD患者的急性加重与治疗;国家自然科学基金资助81170112）;阿斯利康中国呼吸道疾病研究奖 2010 AstraZeneca China Respiratory Research Award;从创新角度分析,