血浆N一端脑利钠钛前体和心钠素水平在慢性肺源性心脏病中的临床意义.PDF

·18· 生旦塞旦医荭2Q堕至i旦筮!鲞筮!璺扭垦蝤些旦堂丛四，丛业!Q塑：!堂!兰，№：!生 血浆N一端脑利钠钛前体和心钠素水平在慢 性肺源性心脏病中的临床意义 梁红卫黄兰卿 【摘要】 目的探讨慢件肺源性心脏病患者血浆N-端脑利钠钛前体(ET-proBNP)和心钠寨(ANP) 的水平及临床意义。方法对46例肺源性心脏病患者及42例正常受试者采用快速化学发光法测定血 浆ET-pmBNP、ANP，并行同步动脉血气分析、肺功能检查，同时应用超声波检测收缩期三尖瓣返流压力 价差(TRPG)估测肺动脉压(PAP)。结果慢性肺源性心脏病患者NT-pmBNP、ANP均显著高于对照组 0．05)。结论血浆NT-pmBNP和ANP共同参与了肺源性心脏病的病理生理过程，测定NT-pmBNP和 ANP水平的变化有助于判断肺源性心脏病病情、严重程度和估计预后。 【关键词】 肺源性心脏病；N-端脑利钠钛前体；心钠素 of natrl- and N·terminal brainnatriurcticandArterial Changesignificanceplasma prohormone peptide nrefic heartdiseaseHANG et peptide呐恤chornicpulmonary Hong—wei．HUANGLan-qina1．Departmentof Diseases，Jiangmen 529051，China Respiratory People’s舶甲n以，^angmen，Guangdong To the levelof andANPandits in 【Abstract】Objective signfiancepatients studyplasma NP—pmBNP heart 46 withchronic disease．MethodsThe levelof andANPweremeasudein pulmonary plasma NT—pmBNP withchronic heartdiseaseand42 chemiluminescence．Simulta- patients pulmonary healthypersonsbyusing blood and testsWaSdone．The valve lungfunction neouslg，arterygasanalysis tricuspidregurgitationpressure Wasusedincontrol Thelev· gradientbiggest(TRIG)in artery group．Results calculatingpulmonarypressure els heart both normal of andANPforc}Ironic disearewere thanthatinthe NT-pmBNP pulmonary group highct control levelof withthe correlatedand group(PO．01)．Theplas