盐酸小檗碱的研究进展.ppt

盐酸小檗碱的研究进展Advances in the study of berberine;一种异喹啉生物碱； 又称黄连素 。 盐类在水中的溶解度都比较小，例如盐酸盐为1∶500，硫酸盐为1∶30。 口服吸收差。;盐酸小檗碱;一、盐酸小檗碱的来源;;主产于四川、湖北、贵州、陕西，主要为栽培。长江南岸、四川石柱及湖北来凤等地的称南岸味连，产量大；长江北岸、四川巫溪、城口及湖北房县等地的称北岸味连，质量佳。销全国，并出口。三角叶黄连主要栽培于四川峨嵋与洪雅，药材名雅连。云连主产于云南德钦、维西、碧江等地，药材名云连。;临床应用;Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages (Department of Microbiology Immunology and Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, Virginia, United States of America.);CONCLUSIONS AND SIGNIFICANCE: Inhibition of ER stress represents a key mechanism by which berberine prevents HIV PI-induced inflammatory response. Our findings provide a new insight into the molecular mechanisms of berberine and show the potential application of berberine as a complimentary therapeutic agent for HIV infection.;临床应用;抑制肿瘤细胞增殖 通过降低细胞内Ca2+浓度抑制COX-2 mRNA表达以及COX-2对花生四烯酸的催化活性,发挥抑制肿瘤细胞增殖的作用。;临床应用;促进肝细胞对葡萄糖的利用 ;Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. (Institute of Integrative Traditional Chinese Western Medicine, Tongji Hospital, Tongji Medical College);The aim of this study is to investigate whether the insulin-sensitizing action of berberine is related to reducing ER stress. Conclusion:The antidiabetic effect of berberine in Hep G2 cells maybe related to attenuation of ER stress and improvement of insulin signal transduction.;抗心律失常 ;降血脂;治疗阿尔茨海默病;其他应用;现有剂型;背景简介;新剂型研究;纳米乳;新剂型研究;新剂型研究;新剂型研究;新剂型研究;新剂型研究;新剂型研究;新剂型研究;新剂型研究;新剂型研究;新剂型研究;国家自然科学基金资助情况统计表 （2005-2010）;国家自然科学基金资助情??统计表 （2005-2010）;