课件：胶质母细胞瘤解析.ppt

Case report Xian central hospital Dang shan New words somnolentia [s?mn?len??r] 嗜睡 morphology [m?:r?fɑ:l?d?i] 形态学 paediatric [?pi:d??tr?k] 儿科的 hydrocephalus[ha?dr?sef?l?s] 脑积水 heterogeneous 成分混杂的 cauliflower 菜花 neuroepithelial 神经上皮的 prognosis 预后 infiltrate 浸润 渗透 Medical history 2-year-old male patient Somnolentia,decrease consciousness 3 hours A Ependymoma B Choroid plexus papilloma C Intraventricular meningioma D Glioblastoma What is your diagnosis? Pathological result Lateral ventricle glioblastoma Immunohistochemistry:GFAP +、S-100 +、Vim +、Syn part+、Ki67 40%、Olig-2 few、CD99 -/+、NeuN -CK -、EMA - Glioblastoma Incidence：Glioblastoma accounts for about 5~7% of all brain tumors in children Peak age：45~55 years old less occur at age lower than 30-year-old Location:Supratentorial white matter most common,especially in frontal and temporal lobes. Morphology:Poorly-marginated ,diffusely-infiltrating necrotic mass. Tumor typically acrosses white matter tracts to involve contralateral hemisphere Prognosis:Poor,1year survival rate is only about 50% NECT Finding：Irregular isodense or hypodense mass with central hypodensity representing necrosis. Marked mass effect and surrouding edema ,tumor infiltration，hemorrage not uncommon，calcification rare CECT Finding：95%have stong,heterogeneous,irregular rim-enhancement T1WI irregular isotense , hypointense white matter mass T2WI heterogeneous,hypointense mass with adjacent tumor infiltration and edema DWI no typically diffusion restriction necrosis,cysts,hemorrage may be seen MR Fin