课件：痛风指南.ppt

Gout results from an excess body burden of uric acid, with hyperuricemia variably defined as a serum urate level exceeding either 6.8 or 7.0 mg/dL. Tissue deposition of monosodium urate monohydrate crystals in supersaturated extracellular fluids of the joints and in certain other sites results in acute gouty arthritis, chronic arthritis, and renal disease. 小剂量阿司匹林的影响可以忽略不计 Senior author Robert Terkeltaub, MD, told?Medscape Medical News,This is the first time in the 78-year history of ACR that there have been guidelines for the management of gout. This indicates how seriously people in rheumatology take this and how common the problem has become, with more than 8 million cases in the US, affecting 3.9% of adults. What we have here is a disease that is very well understood but ridiculously poorly managed. Dr. Terkeltaub is chief of rheumatology at the Veterans Affairs Medical Center in San Diego, California, and professor of medicine and associate division director at the University of California in San Diego. Part 1 of the guidelines focuses on hyperuricemia and CTGA. The top recommendation is for more intensive education of patients on diet, lifestyle choices, treatment objectives, and management of concomitant diseases; this includes recommendations on specific dietary items to encourage, limit, and avoid. We provide a comorbidity check-list for the clinician that I expect will be very useful in day-to-day practice, Dr. Terkeltaub said. We have also provided a cohesive set of diet and lifestyle recommendations. This has been a problem because of the fact and fiction mixed in to diet and lifestyle approaches to gout. The guideline is an advance because it provides a more actionable set of recommendations for physicians to talk about with their patients. * 影响因子9.674 Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens–Johns