课件：ACR痛风指南解读.ppt

为防治尿酸结石的重要措施。 碱化尿液可使尿酸结石溶解。 - 尿液pH 5.5时,尿酸呈过饱和状态，溶解的尿酸减少； - pH 6.5时，大部分尿酸以阴离子尿酸盐的形式存在 将尿pH维持在6.5-6.9范围最为适宜。 常用的碱性药物为碳酸氢钠。 碱 化 尿 液 抑制尿酸合成——代表药物为别嘌呤醇 用法：成人初始剂量一次50mg，一日1～2次，每周可递增50～100mg，至一日200～300mg，分2～3次服，一日最大量不得大于600mg。 Ccr60ml/min，别嘌呤醇推荐剂量为50mg-100mg/日 Ccr15ml/min 禁用 注意事项：别嘌呤醇常见的不良反应为过敏，重度过敏者（迟发性血管炎，剥脱性皮炎）常致死，禁用。肾功能不全增加重度过敏的发生危险，应用时应注意监测。服用期间定期查肝肾功能、血常规，肝肾功能和血细胞进行性下降停用。严重肝功能不全和明显血细胞低下者禁用。 谢 谢！ 后面内容直接删除就行 资料可以编辑修改使用 资料可以编辑修改使用 主要经营：网络软件设计、图文设计制作、发布广告等 公司秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 Today I would like to talk about gout. Gout is a very common disease and one of the few curable diseases treated by rheumatologists. We have typically treated gout by lowering serum urate levels and using prophylactic medications or nonsteroidal anti-inflammatory drugs and perhaps corticosteroids, either orally or injected into the joint. We have treated gout on the basis of clinical experience and lessons passed down from generation to generation, but we have never had evidence-based guidelines to treat this very common and important condition. In October 2012, the American College of Rheumatology published guidelines for the management of gout and urate-lowering treatment in 2 parts in Arthritis Care and Research. [1,2] I would like to highlight some of the important features of these guidelines. The goal of the 2012 American College of Rheumatology (ACR) guidelines was to develop systematic nonpharmacologic and pharmacologic recommendations for effective treatments in gout with an acceptable risk/benefit ratio. Four specific areas of gout management covered by the guidelines were urate-lowering therapy (ULT), chronic gouty arthritis with tophaceous disease, analgesic and anti-inflammatory management of acute gouty arthritis, and pharmacologic anti-inflammatory prophylaxis of attacks of gouty arthritis. * Gout results from an excess body burden of uric acid, with hyperuricemia variably defined as a serum urate