5.重组人干扰素α2b注射液雾化吸入治疗儿童手足口病的疗效观察.pdfVIP

·404 · 现代药物与临床 Drugs Clinic 第 29 卷 第 4 期 2014 年 4 月 重组人干扰素 α-2b 注射液雾化吸入治疗儿童手足口病的疗效观察 张小丹，田亚坤，熊 芳，牟丹蕾，汪 雯* 首都医科大学附属北京佑安医院，北京 100069 摘 要：目的 观察重组人干扰素 α-2b 注射液雾化吸入治疗儿童手足口病的临床疗效。方法 选取 2013 年 5—9 月来首都 医科大学附属北京佑安医院儿科就诊的患儿 164 例，随机分为治疗组（84 例）和对照组（80 例）。对照组给予对症基础治疗。 治疗组在对照组基础上再加用重组人干扰素 α-2b 注射液 300 万单位，生理盐水 2 mL 稀释，空气压缩雾化吸入，体积流量 4 L/min ，2 次/d ，观察期为 7 d 。3 d 为 1 个疗程，观察 3、6 d 内两组体温、进食及疱疹改善情况。结果 治疗组的效果明显 优于对照组，治疗组的总有效率（98.8% ）高于对照组（91.3% ），差异具有统计学意义（P ＜0.05 ）；同时治疗组3、6 d 内体 温和疱疹情况皆优于对照组，差异具有统计学意义（P ＜0.05 ）；治疗组 3、6 d 进食情况差异无统计学意义。结论 重组人 干扰素 α-2b 注射液雾化吸入对于促进手足口病患儿体温恢复及疱疹愈合方面的临床疗效满意，且安全性好，值得临床进一 步研究推广。 关键词：重组人干扰素α-2b 注射液；手足口病；雾化吸入 中图分类号：R287.5 文献标志码：A 文章编号：1674 - 5515(2014)04 - 0404 - 04 DOI: 10.7501/j.issn.1674-5515.2014.04.019 Clinical observation of Recombinant Human Interferon α-2b Injection by aerosol inhalation in treatment of hand-foot-mouth disease of children ZHANG Xiao-dan, TIAN Ya-kun, XIONG Fang, MOU Dan-lei, WANG Wen Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China Abstract: Objective To observe the clinical efficacy of Recombinant Human Interferon α-2b Injection by aerosol inhalation in treatment of hand-foot-mouth disease of children. Methods The children (164 cases) diagnosed with hand-foot-mouth disease in Beijing YouAn Hospital, Capital Medical University from May to September 2013 were randomly divided into treatment (84 cases) and control (80 cases) groups. The children in the control group were administered with symptomatic treatment. On the basis of the control group, the children in the treatment group were administered with Recombinant Human Interferon α-2b Injection 3 million U, twice daily by compressed air and aerosol inhalation, which was diluted by physiological saline 2 mL.