均按照内容更改调整部分调整内容标注蓝色陈伟炳男汉籍贯.DOC

（均按照附件内容更改调整，部分调整内容标注蓝色） 陈伟炳 男 汉 籍贯：江苏常州 1970.10学历:大学 科室 :皮肤科 研究方向：皮肤性病与皮肤外科 职称：副主任中医师 单位： 江苏省常州市金坛区中医医院 电话： 邮箱： cwb2886338@邮编： 213200 地址：江苏省常州市金坛区沿河西路60号金坛区中医医院 第二作者 陈春妹 金坛区中医医院皮肤 第三作者 范华云 金坛区中医医院皮肤科 1536681896 糖皮质激素联合犀角地黄汤治疗过敏性紫癜的临床观察 陈伟炳1 陈春妹2 范华云3 常州市金坛区中医医院 皮肤科213200 摘要：目的 探讨糖皮质激素联合犀角地黄汤治疗过敏性紫癜（HSP）的疗效。方法 随机数字表法将112例HSP患者分为联合组和对照组各56例。对照组患者予以糖皮质激素（泼尼松，1mg/d）治疗12周；联合组患者在对照组基础上联合犀角地黄汤口服。比较两组患者治疗前后T淋巴细胞亚群（CD4+、CD8+、CD4+/CD8+）、24h尿蛋白定量、血清肌酐（SCr）、血清白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)水平的变化，记录其治疗后12个月内复发率。结果 治疗12周时，两组患者CD4+、CD4+/CD8+检测结果均较治疗前明显提高，且联合组＞对照组（P＜0.05）；CD8+、24h尿蛋白定量、血清SCr和血清IL-1β、IL-10水平均较治疗前明显降低，且联合组＜对照组（P均＜0.05）。随访12个月内，联合组HSP复发率明显低于对照组（P＜0.05）。结论 糖皮质激素联合犀角地黄汤疗法对改善HSP患者免疫功能状态、调节其炎症反应程度、减轻肾损害等方面具有积极意义。 关键词：犀角地黄汤；糖皮质激素；过敏性紫癜；疗效；肾功能；免疫功能 Observation on glucocorticoids combined with Rhinoceros Horn and Rehmannia Decoction in the treatment of Henoch-Schonlein purpura Chen Weibing 1, Chen Chunmei 2, Fan Huayun 3 Department of Dermatology, Jintan Hospital of Traditional Chinese Medicine, Changzhou 213200, China Abstract: Objective To investigate the curative effect of glucocorticoids combined with Rhinoceros Horn and Rehmannia Decoction in the clinical treatment of Henoch-Schonlein purpura (HSP). Methods A total of 112 patients with HSP were divided into the combined group and the control group by random number table method, 56 cases in each group. The control group were treated with glucocorticoid (prednisone, 1 mg/d) for 12 weeks while the combined group were additionally treated with Rhinoceros Horn and Rehmannia Decoction. Changes of the levels of T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+), renal function indexes [24h urine protein quantitation, serum creatinine (SCr)], serum interleukin -1 β (IL-1 β) and interleukin -10 (IL-10) in the two groups before and after treatment were compared. The recurrence rate within 12 months after treatment was recorded. Results After 12 weeks of trea