健胃消食口崩片药效学研究-天津中草药杂志社.PDF

- 432 - Drug Evaluation Research 第 34 卷 第 6 期 2011 年 12 月 健胃消食口崩片药效学研究 1 1 2 刘旭海 ，季巧遇 ，彭旦明 1. 江中药业股份有限公司，江西 南昌 330096 2. 江西省中医药研究院，江西 南昌 330046 摘 要：目的 探讨健胃消食口崩片的药理作用并与原剂型健胃消食片进行药效比较。方法 采用生大黄和利血平造成脾虚 动物模型，观察健胃消食口崩片对脾虚动物胃排空、小肠推进运动、血清淀粉酶活力及胃液分泌等的影响。结果 健胃消食 口崩片具有加快脾虚小鼠胃排空和小肠推进运动，提高脾虚小鼠血清淀粉酶活力，提高脾虚小鼠胸腺系数和体质量增加，延 长冰浴中小鼠游泳时间，促进大鼠胃液分泌及胃酸排出等作用。结论 健胃消食口崩片可以有效改善动物脾虚和消化不良症 状，与原剂型疗效相当。 关键词：健胃消食口崩片；药效学；脾虚；消化不良 中图分类号：R975.1 文献标志码：A 文章编号：1674 - 6376 (2011) 06 - 0432 - 04 Pharmacodynamics of Jianwei Xiaoshi Orally Disintegrating Tablets 1 1 2 LIU Xu-hai , JI Qiao-yu , PENG Dan-ming 1. Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330096, China 2. Jiangxi Institute of Traditional Chinese Medicine, Nanchang 330046, China Abstract: Objective To dicuss the pharmacological effects of Jianwei Xiaoshi Orally Disintegrating Tablets (JXODTs) and to compare the potency between Jianwei Xiaoshi Pills (JXPs) and JXODTs. Methods Animal model of spleen deficiency was established using rhubarb and Reserpine and the effects of JXODTs on gastric emptying, small intestine movement, serum amylase activity, and secretion of gastric juice were observed. Results JXODTs have the effects on accelerating gastric emptying and intestinal propulsion in mice spleen campaign to raise serum amylase deficiency, increasing spleen weight and thymus weight coefficients, extending swimming time of mice in an ice bath, promoting the gastric acid secretion and excretion of rats and so on. Conclusion JXODTs could better improve the state of animal spleen deficiency and indigestion, with the considerable effect of the original formulation. Key words: Jianwei Xiaoshi Orally Disintegrating Tablets (JXODTs); pharmacodynamics; spleen deficiency; ind