肿瘤相关巨噬细胞在重塑肿瘤免疫微环境中的作用_郭秋均.pdfVIP

922 2013 10 33 10 TUMOR Vol. 33, October 2013 DOI: 10.3781/j.issn.1000-7431.2013.10. 014 Copyright© 2013 by TUMOR Review 郭秋均李　杰 100053 R730.3 A 1000-7431 (2013) 10-0922-06 The role of tumor-associated macrophages in remodeling tumor immune microenvironment GUO Qiu-jun, LI Jie Department of Oncology, Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Majority of experimental and clinical studies have shown a pro-tumoral function of tumor- associated macrophages (TAMs) which occupy a large part in matrix cells. TAMs promote tumor cell invasion and migration, and their number is related to malignant degree and poor prognosis. Macrophages plasticity makes it possible to change the tumor microenvironment and remodel tumor immune in cancer immunotherapy. Increasing researches have revealed the TAMs effect on tumor microenvironment and put forward tumor immune treatments aiming at TAMs. Here this review presents the recent research of TAMs in remodeling tumor immune microenvironment and immune targeted therapies, such as the origin of TAMs, the immunosuppression effect of TAMs on tumor microenvironment, tumor extracellular matrix remodeling, and promotion of angiogenesis and lymphangiogenesis Neoplastic processes; Macrophages; Tumor escape; Immunotherapy, tumor; Neoplastic microenvi